Junctophilin 1 Protein (JPH1) (AA 1-660) (His tag)

Catalog No. ABIN7565073

Product Details

Target: Junctophilin 1 (JPH1)

Protein Type: Recombinant

Protein Characteristics: AA 1-660

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This Junctophilin 1 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Jph1 Protein expressed in mammalian cells.

Sequence: MTGGRFDFDD GGTYCGGWEE GKAHGHGICT GPKGQGEYSG SWSHGFEVVG VYTWPSGNTY QGYWAQGKRH GLGVETKGKW MYRGEWSHGF KGRYGVRQSL CTPARYEGTW SNGLQDGYGV ETYGDGGTYQ GQWAGGMRHG YGVRQSVPYG MATVIRSPLR TSLASLRSEQ SNGSVLHEAA AAAADSPAGT RGGFVLNFHA DTELGKKKGG LFRRGSLLGS MKLRKSESKS SISSKRSSVR SDAAMSRISS SDANSTISFG DVDCDFCPVE DHVDATTTET YMGEWKNDKR NGFGISERSN GMKYEGEWAN NKRHGYGCTV FPDGSKEEGK YKNNILVRGI RKQLIPIRNT KTREKVDRAI EGAQRAAAMA RTKVEIANSR TAHARAKADA ADQAALAARQ ECDIARAVAR ELSPDFYQPG PDYIKQRCQE GGDIKENPEE KVLEKPPSPK ESPHFYRKGT TPPRSPESSP KQSHSPQPSS PEPSKKQNPS PGARLSQDKQ SLAEEQVTAF VNKPSMSKAP AKELGASVSK YSGRHHVPNP SNGELHSQYH GYYVKLNTPQ HPPEDREDDR GVSQSSSALV PRPSPNKWGP PKSVTKPVAK ESKTEPKAKK SELAIPKNPA SNDTCPSLEK EANSGPNSIM IVLVMLLNIG LAILFVHFLT Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: Junctophilin 1 (JPH1)

Alternative Name: Jph1 (JPH1 Products)

Background: Junctophilin-1 (JP-1) (Junctophilin type 1),FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. {ECO:0000269|PubMed:11535622, ECO:0000269|PubMed:12135771, ECO:0000269|PubMed:12729900}.

Molecular Weight: 71.9 kDa

UniProt: Q9ET80

AlphaFold: Q9ET80