GFRAL Protein (AA 19-351) (Fc Tag)
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- Target See all GFRAL Proteins
- GFRAL (GDNF Family Receptor alpha Like (GFRAL))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 19-351
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GFRAL protein is labelled with Fc Tag.
- Purpose
- GFRAL (human):Fc (human) (rec.)
- Cross-Reactivity
- Human
- Characteristics
- The extracellular domain of human GFRAL (aa 19-351) is fused to the N-terminus of the Fc region of human IgG1.
- Purity
- >98 % (SDS-PAGE)
- Sterility
- Sterile filtered
- Endotoxin Level
- <1EU/mg purified protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.
- Top Product
- Discover our top product GFRAL Protein
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GDNF Family Receptor alpha Like (GFRAL) protein (His-Avi Tag)
GFRAL Origin: Mouse Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
GDNF Family Receptor alpha Like (GFRAL) (AA 19-351) protein (His-Avi Tag)GFRAL Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
GDNF Family Receptor alpha Like (GFRAL) (AA 19-351) protein (His-Avi Tag,Biotin)GFRAL Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
GDNF Family Receptor alpha Like (GFRAL) (AA 19-351) protein (Fc Tag)GFRAL Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
GDNF Family Receptor alpha Like (GFRAL) (AA 20-351) protein (His-Avi Tag)GFRAL Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
GDNF Family Receptor alpha Like (GFRAL) (AA 20-350) protein (His-Avi Tag,Biotin)GFRAL Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
GDNF Family Receptor alpha Like (GFRAL) (AA 20-351) protein (His-Avi Tag,Biotin)GFRAL Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
GDNF Family Receptor alpha Like (GFRAL) (AA 19-351) protein (His tag)GFRAL Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- GFRAL (GDNF Family Receptor alpha Like (GFRAL))
- Alternative Name
- GFRAL (GFRAL Products)
- Background
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GDNF Family Receptor alpha-like, Gral, Glial Cellline-derived Neurotrophic Factor Receptor alpha-like, GFR alpha-like, C6orf144
GFRAL (GDNF receptor alpha-like) is a distant member of the GDNFR family of proteins. Human GFR alpha-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72 % and 71 % identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.
- Molecular Weight
- ~50-100kDa
- NCBI Accession
- NP_997293
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