IL-6 Receptor Protein (AA 20-357) (Fc Tag)
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- Target See all IL-6 Receptor (IL6R) Proteins
- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 20-357
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Origin
- Mouse
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Source
- CHO Cells
- Purification tag / Conjugate
- This IL-6 Receptor protein is labelled with Fc Tag.
- Purpose
- IL-6R (mouse):Fc (mouse) (rec.)
- Cross-Reactivity
- Mouse
- Characteristics
- The extracellular domain of mouse IL-6R (aa 20-357) is fused to the N-terminus of the Fc region of mouse IgG2a.
- Purity
- >98 % (SDS-PAGE)
- Sterility
- Sterile filtered
- Endotoxin Level
- <1EU/mg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.
- Top Product
- Discover our top product IL6R Protein
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Interleukin 6 Receptor (IL6R) (AA 20-365) protein (His tag)
IL6R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Interleukin 6 Receptor (IL6R) (AA 20-365) protein (Fc Tag)IL6R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 6 Receptor (IL6R) (AA 229-468) protein (His-IF2DI Tag)IL6R Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 6 Receptor (IL6R) (AA 1-468) protein (GST tag)IL6R Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
- Alternative Name
- IL-6R (IL6R Products)
- Background
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Interleukin-6 Receptor Subunit alpha, IL6RA, CD126
Interleukin 6 receptor (IL-6R, CD126) is a type I cytokine receptor, which is a protein complex consisting of an IL-6 receptor subunit (IL-6R) and interleukin 6 signal transducer glycoprotein 130 (gp130). It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL-6 and IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
- Molecular Weight
- ~70-85kDa
- Pathways
- JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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