VSIG4 Protein (AA 20-283) (Fc Tag)
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- Target See all VSIG4 Proteins
- VSIG4 (V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-283
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This VSIG4 protein is labelled with Fc Tag.
- Purpose
- VSIG4 (human):Fc (mouse) (rec.)
- Cross-Reactivity
- Human
- Characteristics
- The extracellular domain of human VSIG4 (aa 20-283) is fused to the N-terminus of the Fc region of mouse IgG2a.
- Purity
- >98 % (SDS-PAGE)
- Sterility
- Sterile filtered
- Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
- Top Product
- Discover our top product VSIG4 Protein
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V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) (AA 20-283) protein (His tag)
VSIG4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) (AA 25-288) protein (His tag)VSIG4 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) protein (His tag,Fc Tag)VSIG4 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) protein (His tag)VSIG4 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- VSIG4 (V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4))
- Alternative Name
- VSIG4 (VSIG4 Products)
- Background
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V-set and immunoglobulin domain containing 4, Z39Ig, CRIg
VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.
- Molecular Weight
- ~68kDa (SDS-PAGE)
- UniProt
- Q9Y279
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