EIF3A Protein (AA 1-325) (His tag)
EIF3A
Origin: Human
Host: Baculovirus infected Insect Cells
Recombinant
> 90% by SDS-PAGE
SDS
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- Target See all EIF3A Proteins
- EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-325
- Origin
- Human
- Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This EIF3A protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
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MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG FDFGGNIIMF STDKQMGYQC FVSFFDLRDP SQIDNNEPYM KIPCNDSKIT SAVWGPLGEC IIAGHESGEL NQYSAKSGEV LVNVKEHSRQ INDIQLSRDM TMFVTASKDN TAKLFDSTTL EHQKTFRTER PVNSAALSPN YDHVVLGGGQ EAMDVTTTST RIGKFEARFF HLAFEEEFGR VKGHFGPINS VAFHPDGKSY SSGGEDGYVR IHYFDPQYFE FEFEA
- Purity
- > 90% by SDS-PAGE
- Endotoxin Level
- < 1 EU per 1ug of protein (determined by LAL method)
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
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- Target
- EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))
- Alternative Name
- eIF-3 beta/EIF3I (EIF3A Products)
- Background
- EIF3I, also known as eukaryotic translation initiation factor 3 subunit I, is a multiprotein complex that functions during the initiation phase of eukaryotic translation. This protein is one out of 13 subunits of the mammalian EIF3 complex which associated with the 40S ribosome and facilitates the formation of 43S pre-initiation complex. This complex stimulates nearly all steps of translation initiation. These factors also appear to participate in other phases of translation, such as recycling, where it promotes the splitting of post-termination ribosomes. Also, it is shown to act as a signaling transducer by bind to and activating AKT1 through preventing PP2A-induced AKT1 dephosphorylation in tumor cells. Recombinant Human EIF3I, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
- Molecular Weight
- 37.3 kDa (331aa)
- NCBI Accession
- NP_003748
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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