GP1BB Protein (AA 26-147) (His tag)

Catalog No. ABIN7596377

Product Details

Target: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Protein Type: Recombinant

Protein Characteristics: AA 26-147

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This GP1BB protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: CPAPCSC AGTLVDCGRR GLTWASLPTA FPVDTTELVL TGNNLTALPP GLLDALPALR TAHLGANPWR CDCRLVPLRA WLAGRPERAP YRDLRCVAPP ALRGRLLPYL AEDELRAACA PGPLC

Purity: > 95% by SDS-PAGE

Endotoxin Level: < 1 EU per 1ug of protein (determined by LAL method)

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details

Target: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Alternative Name: GP1BB (GP1BB Products)

Background: GP1BB, also known as glycoprotein Ib platelet subunit beta/CD42c, is a member of platelet receptor family. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. This complex is composed of GPIb alpha attached to GPIb beta and non-covalently complexed with GPIX and GPV. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in GP1BB have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. Recombinant human GP1BB, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Molecular Weight: 14kDa (131aa)

NCBI Accession: NP_000398