IL36A/IL1F6 Protein (AA 6-158) (Fc Tag)

Catalog No. ABIN7597251

Recombinant IL36A/IL1F6 protein expressed in HEK-293 Cells.

Quick Overview for IL36A/IL1F6 Protein (AA 6-158) (Fc Tag) (ABIN7597251)

Target: IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 6-158

Purification tag / Conjugate: This IL36A/IL1F6 protein is labelled with Fc Tag.

Purpose: Recombinant human IL36A Protein with C-terminal human Fc tag

Sequence: IL36A(Lys6-Phe158) hFc(Glu99-Ala330)

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))

Alternative Name: IL36A

Background: FIL1, FIL1E, IL1F6, IL-1F6, IL1(EPSILON), FIL1(EPSILON)
The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]

Molecular Weight: predicted molecular mass of 43.2 kDa after removal of the signal peptide. The apparent molecular mass of IL36A-hFc is 35-70 kDa due to glycosylation.

UniProt: Q9UHA7

Pathways: Cancer Immune Checkpoints