ACVA Protein

Catalog No. ABIN7668105

Recombinant ACVA protein expressed in Escherichia coli (E. coli).

Quick Overview for ACVA Protein (ABIN7668105)

Target: ACVA (Activin A (ACVA))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human, Mouse, Rat

Source: Escherichia coli (E. coli)

Application: Cell Culture (CC)

Purity: > 95 %

Product Details

Purpose: Recombinant Human/Mouse/Rat Activin A protein(His Tag)

Sequence: Gly 311-Ser 426

Sterility: 0.2 μm filtered

Endotoxin Level: < 0.1 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measure by its ability to inhibit the proliferation of mouse MPC-11 cells. The ED₅₀ for this effect is <10 ng/mL. The specific activity of recombinant human Activin A is approximately >1.0 x 10³ IU/mg.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: ACVA (Activin A (ACVA))

Alternative Name: Activin A

Background: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.,Activin A,INHBA,Inhibin beta A chain

Molecular Weight:

calculated_mw: 13.1 kDa

observed_mw: 15 kDa

UniProt: P08476

Pathways: Hormone Transport, Peptide Hormone Metabolism