Troponin I Protein (TNNI)

Catalog No. ABIN934718

This Native Troponin I protein is produced in Human. There is 1 publication available.

Quick Overview for Troponin I Protein (TNNI) (ABIN934718)

Target: Troponin I (TNNI)

Protein Type: Native

Origin: Human

Source: Human

Purity: > 99 % pure

Product Details

Characteristics: Purified native Human Troponin I protein (Cardiac)
Protein Source: Human cardiac tissue

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a liquid in 8 M Urea buffer with 30 mM NaCl, 50 mM Tris. HCl, 15 mM beta-mercaptoethanol, 1 mM EGTA, pH 8.0

Precaution of Use: Donor samples were tested and found to be negative for HBsAg, Anti-HIV-1/HIV-2, & HCV. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20 °C to -70 °C,

References

Mulvaney, Cole, Kniller, Malito, Tamanaha, Rife, Stanton, Whitman: "Rapid, femtomolar bioassays in complex matrices combining microfluidics and magnetoelectronics." in: Biosensors & bioelectronics, Vol. 23, Issue 2, pp. 191-200, (2007) (PubMed).

Target Details

Target: Troponin I (TNNI)

Alternative Name: Troponin I

Background: Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.
Description: Human cardiac tissue.