ARTN Protein
Quick Overview for ARTN Protein (ABIN935222)
Target
See all ARTN ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG
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Characteristics
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Purified recombinant Human Artemin protein
Expression System: E.coli
Bioactivity: Determined by it's ability to promote survival and neurite outgrowth and dorsal root ganglion neurons. -
Purification
- Heat shock method
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Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Artemin (ARTN) (AA 112-224) protein (Fc Tag)
ARTN Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Artemin (ARTN) (AA 108-220) protein (His-IF2DI Tag)ARTN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Artemin (ARTN) (AA 1-228) protein (GST tag)ARTN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Artemin (ARTN) proteinARTN Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
Artemin (ARTN) proteinARTN Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- ARTN (Artemin (ARTN))
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Alternative Name
- Artemin
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Background
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Artemin is a disulfide-linked homodimeric neurotrophic factor structurally related to GDNF, Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. Artemin, GDNF, Persephin and Neurturin all signal through a multicomponent receptor system, composed of RET (receptor tyrosine kinase) and one of the four GFRalpha (alpha1-alpha4) receptors. Artemin prefers the receptor GFRalpha3-RET, but will use other receptors as an alternative. Artemin supports the survival of all peripheral ganglia such as sympathetic, neural crest and placodally derived sensory neurons, and dompaminergic midbrain neurons.
Alternative Names: EVN protein, Enovin protein, ART protein, Neublastin protein , ARTN protein, NBN protein -
Molecular Weight
- 24.4 kDa
Target
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