Interleukin 10 (IL10) (Active) Protein

Details for Product No. ABIN935529
Protein Name
  • CSIF
  • GVHDS
  • IL-10
  • IL10A
  • TGIF
  • Il-10
  • IL10X
  • interleukin 10
  • IL10
  • Il10
Origin
Human
69
30
18
4
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Source
Escherichia coli (E. coli)
93
26
16
11
4
2
1
Protein Type
Recombinant
Biological Activity
Active
Options
Sequence SKGHSIKGDN NCTHFPVSQT HMLRELRAAF SQVKTFFQKK DQLDNIVLTD SLLQDFKGYL GCQALSEMIK FYLVEVMPQA ENHGPEIKEH LNSLGEKLKT LWIQLRRCHR FLPCENKSKA VEQVKNDFNK LQDKGVYKAM NEFDIFINCI EAYVTLKMKN
Characteristics Purified recombinant Human IL10 protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent inhibition of antigen-specific T cell proliferation is less than 10ng/mL.
Purity > 98 % pure
Endotoxin Level < 0.1 ng per µg (1 EU/µg).
Protein Name
Background IL10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL10 inhibits the expression of proinflammatory cytokines such as IL1 and TNFa. Like IL4, IL10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL10 active on Mouse cells, but Mouse IL10 is inactive on human cells.
Alternative Names: CSIF protein, B-TCGF protein, TGIF protein, IL 10 protein, Interleukin 10 protein, IL-10 protein, IL10, IL 10, IL-10 protein, IL-10
Molecular Weight 18.7 kDa
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
Buffer Lyophilized from 20 mM Na3PO4, pH 7.0.
Handling Advice Avoid repeated freeze/thaw cycles.
Storage RT/-20 °C
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