GM-CSF Protein
-
- Target See all GM-CSF (CSF2) Proteins
- GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))
- Protein Type
- Recombinant
- Biological Activity
- Active
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Sequence
- MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQana lysis The sequence of the first five N-terminal amino acids has been found to be (Met)-Ala-Pro-Ala-Arg-Ser
- Characteristics
- Determined by the dose-dependant stimulation of human TF-1 cells. The ED50 for this effect is 0.24-0.36 ng/ml.
- Purity
- > 95 % by SDS-PAGE and Commassie blue staining
- Endotoxin Level
- Level Less than 0.1 ng/µg (1 EU/myg) determined by LAL tes
- Top Product
- Discover our top product CSF2 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Storage
- -20 °C
-
- Target
- GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))
- Alternative Name
- Granulocyte Macrophage Colony Stimulating Factor (CSF2 Products)
- Background
- GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Synonym: GM-CSF, E.coli2. Formulation: Lyophilized from a 0.2 mym filtered solution in 2 mM PB, pH 7.4.
- Pathways
- JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin
-