-
A voltage-gated proton channel (Hv1) is the main pathway for H(+) efflux that allows capacitation in sperm and permits sustained reactive oxygen species production in white blood cells. A designed peptide inhibitor C6 was identified by a phage-display strategy whereby approximately 1 million novel peptides were fabricated on an inhibitor cysteine knot scaffold and sorted on purified Hv1 protein.
-
The authors now report that R1H mutation is sufficient to reconstitute resting-state H(+) 'shuttle' conductance in Hv1 without abrogating the intrinsic 'aqueous' H(+) conductance.
-
We suggest that cleavage and heterodimerization of Hv1 represents an adaptation to the specific requirements of pH control in sperm.
-
Inhibition of Hv1 channels by Zn(2+).
-
CREBBP mutations were associated with inferior progression-free survival (PFS), whereas mutations in previously unreported HVCN1, a voltage-gated proton channel-encoding gene and B-cell receptor signaling modulator, were associated with improved PFS.
-
Trp207 is crucial for slow channel opening, highly temperature-dependent gating kinetics, proton selectivity, and DeltapH-dependent gating.
-
Our data demonstrated that the expression of Hv1 in pancreatic islet beta-cells regulates insulin secretion through regulating Ca(2+) homeostasis.
-
The main properties of the voltage-gated proton channel (HV1) are described in this review, along with what is known about how the channel protein structure accomplishes its functions. [review]
-
Hv1 activity displays hysteresis
-
A shorter isoform of HVCN1 with enhanced gating is specifically enriched in malignant B cells.
-
Divalent metal binding causes a conformational change in human the Hv1 c-terminal domain.
-
analysis of of the C-terminal domain of voltage-gated proton channel HV1 and the thermodynamic characteristics of Zn(2) binding to this domain
-
Salt bridge networks and the hydrophobic plug function as the gate in Hv1 channels; outward movement of the fourth transmembrane segment leads to the opening of this gate.
-
Results suggest that Hv1 may be used as a potential biomarker for diagnosis and prognosis of colorectal carcinoma, and a potential target for anticancer drugs in colorectal cancer therapy.
-
inhibition of Hv1 activity via Zn(2+) ions can effectively retard the cancer growth and suppress the cancer metastasis by the decrease of proton extrusion and the down-regulation of gelatinase activity
-
In the Hv1 voltage-gated channel a highly conserved phenylalanine is found in the charge transfer center.
-
Two conformational changes are detected in Hv1 channels that are involved in channel opening.
-
inhibition of Hv1 function via knockdown of Hv1 expression can effectively retard cancer growth
-
Hv1 channels maintain a physiological membrane potential during the respiratory burst of neutrophils by providing a compensating charge for the electrons transferred by NOX2 from NADPH to superoxide.
-
Hv1-dependent reactive oxygen species production is responsible for a substantial fraction of brain damage at early time points after ischemic stroke.
