HVCN1 antibody (C-Term)

Catalog No. ABIN6991389

The Rabbit Polyclonal anti-HVCN1 antibody (ABIN6991389) specifically detects HVCN1 in WB, ELISA, IHC (p) and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for HVCN1 antibody (C-Term) (ABIN6991389)

Target: HVCN1 (Hydrogen Voltage-Gated Channel 1 (HVCN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HVCN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-HVCN1 Antibody

Binding Specificity: C-Term

Purification: HVCN1 Antibody is affinity chromatography purified via peptide column.

Immunogen: HVCN1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human HVCN1. The immunogen is located within the last 50 amino acids of HVCN1.

Isotype: IgG

Application Details

Application Notes: HVCN1 antibody can be used for detection of HVCN1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: HVCN1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: HVCN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for HVCN1

Target: HVCN1 (Hydrogen Voltage-Gated Channel 1 (HVCN1))

Alternative Name: HVCN1

Background: HVCN1 Antibody: HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.

Molecular Weight: Predicted: 30 kDa

Observed: 30 kDa

Gene ID: 84329

NCBI Accession: NP_115745

UniProt: Q96D96

Pathways: Proton Transport