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anti-Rat (Rattus) Antibodies:
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Studies show that phosphorylation of the NHE3 (show SLC9A3 Antibodies) at a single amino acid in the distal part of the C-terminus affects multiple aspects of NHE3 (show SLC9A3 Antibodies) complex formation and changes the NHE3 (show SLC9A3 Antibodies) lipid raft distribution, which cause changes in specific aspects of basal as well as acutely stimulated and inhibited Na(+)/H(+) exchange activity.
These data indicate that the acid-dependent NHE2 stimulation is implemented by transcriptional upregulation of NHE2 via acid-induced Egr-1 (show EGR1 Antibodies) in the intestinal epithelial cells.
Phosphorylation of nPKC-delta results in activation of ERK1/2 kinase and subsequent induction of Egr-1. Subsequently, Egr-1 directly targets NHE2 promoter and promotes NHE2 transcriptional upregulation by interaction with NHE2-PMA response element.
In humans, NHE2 transcripts appear to be gestationally regulated, which may contribute to changes in NHE activity.
expression of the human NHE2 promoter is controlled by Sp1 (show PSG1 Antibodies) and Sp3 by interactions with the proximal promoter and the transcription initiation site of NHE2
No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II (show CA2 Antibodies), CA IV (show CA4 Antibodies), CA XIV (show CA14 Antibodies), kNCB1, NHE3 (show SLC9A3 Antibodies), NHE8 (show SLC9A8 Antibodies), NHRF1, NHRF2 and SLC26A6 (show SLC26A6 Antibodies) amplified from genomic DNA of family members with pRTA.
T84 human colon cells contain three isoforms of the Na+/H+ exchanger, NHE1 (show SLC9A1 Antibodies), NHE2, and NHE4 (show SLC9A4 Antibodies), but not the Cl-dependent NHE
Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA (show SLC26A3 Antibodies) and the apical Na+/H+ exchangers NHE2 and NHE3 (show SLC9A3 Antibodies) in intestinal epithelial cells.
Report morphological adaptation with preserved proliferation/NHE2 content in the colon of patients with short bowel syndrome.
The functional and molecular expression of NHEs in cultured human endolymphatic sac (show ADCY10 Antibodies) (ES) epithelial cells was determined and the effect of IFN-gamma (show IFNG Antibodies) on NHE function, was examined.
functional NHE2, but not NHE1 (show SLC9A1 Antibodies), is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2
thick ascending cells retain structural and functional properties of their in vivo thick ascending counterparts and express functional NHE2 protein in the apical membrane, which may be inhibited by nitric oxide
High NHE2 expression in crypts. Role for NHE2 in cryptal pH(i) and volume homeostasis.
Bicarbonate reabsorption in the distal tubule of mice with genetic knockouts at NHE2 or NHE3 (show SLC9A3 Antibodies).
This study demonstrated that constitutive absence of NHE2 results in a compensatory increase in a Na(+)-dependent, EIPA-sensitive acid extruder distinct from NHE1 (show SLC9A1 Antibodies), NHE3 (show SLC9A3 Antibodies), or SITS-sensitive transporters.
Here, we show that NHE10 (show NHEDC2 Antibodies) is highly expressed in OCs in response to receptor activator of nuclear factor-kappaB ligand signaling and is required for OC differentiation and survival.
Renal tissue renin (show REN Antibodies) activity and plasma renin (show REN Antibodies) concentration were elevated three- and twofold, respectively, in NHE2 knckout mice.
Mucosa from NHE2(-/-) mice displayed a shift of occludin (show OCLN Antibodies) and claudin-1 (show CLDN1 Antibodies) expression to the Triton-X-soluble membrane fractions and showed disruption of occludin (show OCLN Antibodies) and claudin-1 (show CLDN1 Antibodies) localization patterns following injury.
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
, Na(+)/H(+) exchanger 2
, sodium/hydrogen exchanger 2
, solute carrier family 9 (sodium/hydrogen exchanger)
, solute carrier family 9 (sodium/hydrogen exchanger), member 2
, solute carrier family 9 member 2
, Na/H ion exchanger
, Solute carrier family 9 (sodium/hydrogen exchanger 2), antiporter 2, Na+/H+ (Na+/H+ exchanger 2)
, solute carrier family 9, member 2
, sodium/hydrogen exchanger 2 (nhe2)
, solute carrier family 9 sodium/hydrogen exchanger member 2
, sodium hydrogen exchanger 2