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Studies show that phosphorylation of the NHE3 at a single amino acid in the distal part of the C-terminus affects multiple aspects of NHE3 complex formation and changes the NHE3 lipid raft distribution, which cause changes in specific aspects of basal as well as acutely stimulated and inhibited Na(+)/H(+) exchange activity.
These data indicate that the acid-dependent NHE2 stimulation is implemented by transcriptional upregulation of NHE2 via acid-induced Egr-1 in the intestinal epithelial cells.
Phosphorylation of nPKC-delta results in activation of ERK1/2 kinase and subsequent induction of Egr-1. Subsequently, Egr-1 directly targets NHE2 promoter and promotes NHE2 transcriptional upregulation by interaction with NHE2-PMA response element.
In humans, NHE2 transcripts appear to be gestationally regulated, which may contribute to changes in NHE activity.
expression of the human NHE2 promoter is controlled by Sp1 and Sp3 by interactions with the proximal promoter and the transcription initiation site of NHE2
No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA.
T84 human colon cells contain three isoforms of the Na+/H+ exchanger, NHE1, NHE2, and NHE4, but not the Cl-dependent NHE
Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cells.
Report morphological adaptation with preserved proliferation/NHE2 content in the colon of patients with short bowel syndrome.
The functional and molecular expression of NHEs in cultured human endolymphatic sac (ES) epithelial cells was determined and the effect of IFN-gamma on NHE function, was examined.
Expression of solute carrier family 40 (iron-regulated transporter) member 1 (Slc40a1) within the mammary gland can mediate the effect of milk mineral concentration quantitative trait loci 9 (Mmcq9) on milk iron concentration.
functional NHE2, but not NHE1, is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2
thick ascending cells retain structural and functional properties of their in vivo thick ascending counterparts and express functional NHE2 protein in the apical membrane, which may be inhibited by nitric oxide
High NHE2 expression in crypts. Role for NHE2 in cryptal pH(i) and volume homeostasis.
Bicarbonate reabsorption in the distal tubule of mice with genetic knockouts at NHE2 or NHE3.
This study demonstrated that constitutive absence of NHE2 results in a compensatory increase in a Na(+)-dependent, EIPA-sensitive acid extruder distinct from NHE1, NHE3, or SITS-sensitive transporters.
Here, we show that NHE10 is highly expressed in OCs in response to receptor activator of nuclear factor-kappaB ligand signaling and is required for OC differentiation and survival.
Renal tissue renin activity and plasma renin concentration were elevated three- and twofold, respectively, in NHE2 knckout mice.
Mucosa from NHE2(-/-) mice displayed a shift of occludin and claudin-1 expression to the Triton-X-soluble membrane fractions and showed disruption of occludin and claudin-1 localization patterns following injury.
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
, Na(+)/H(+) exchanger 2
, sodium/hydrogen exchanger 2
, solute carrier family 9 (sodium/hydrogen exchanger)
, solute carrier family 9 (sodium/hydrogen exchanger), member 2
, solute carrier family 9 member 2
, Na/H ion exchanger
, Solute carrier family 9 (sodium/hydrogen exchanger 2), antiporter 2, Na+/H+ (Na+/H+ exchanger 2)
, solute carrier family 9, member 2
, sodium/hydrogen exchanger 2 (nhe2)
, solute carrier family 9 sodium/hydrogen exchanger member 2
, sodium hydrogen exchanger 2