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High Tescalcin expression is associated with colorectal cancer.
CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation.
This study demonstrated that highly significant effects of rs7294919 of tescalcin on hippocampal gray matter volumes.
a binding partner and regulator of subunit 4 of the COP9 (show COPS8 Proteins) signalosome
TESC is overexpressed in colorectal cancer
Loss of both N-myristoylation and calcium binding of CHP3 decreases cell surface stability of NHE1 (show SLC9A1 Proteins).
Tescalcin is one of the key gene products that is involved in switching differentiation program in some cell types.
CHP3 binds directly to the proximal juxtamembrane C-terminal region (amino acids 505-571) of rat NHE1 (show SLC9A1 Proteins) in the same region that binds CHP1 (show CHP Proteins) and CHP2.
TESC has an important role in mediating the neuroprotective effect of class I histone deacetylase (show HDAC1 Proteins) inhibitors, and may also be involved in the development of brain and neurodegenerative diseases through epigenetic mechanisms
Tescalcin does not appear to be necessary for normal megakaryocyte development
CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation.
the data demonstrated that Sp1 (show SP1 Proteins) and Sp3 transcription factors cooperate positively in the regulation of Tesc promoter, and that the putative ZF5 (show ZFP161 Proteins) motif is critical for its activation.
Tescalcin shares sequence and functional homology with calcineurin-B homologous protein (CHP), and like CHP can inhibit the phosphatase activity of calcineurin A.
Studies indicate very specific expression of Tesc in various tissues in chicken and mouse during embryologic development, and conservation of Tesc expression in both species.
Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation (By similarity).
calcineurin B homologous protein 3
, calcineurin-like EF hand protein 3