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anti-Mouse (Murine) Coronin 1a Antibodies:
anti-Rat (Rattus) Coronin 1a Antibodies:
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Mammalian Polyclonal Coronin 1a Primary Antibody for IHC (fro), IF - ABIN542475
Appleton, Wu, Wiesmann: The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. in Structure (London, England : 1993) 2006
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Polyclonal Coronin 1a Primary Antibody for IF, WB - ABIN540866
Ahmed, Shaw, Sharma, Yang, McGowan, Dickson: Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007
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Human Monoclonal Coronin 1a Primary Antibody for IHC (p), ELISA - ABIN564843
Moriceau, Kantari, Mocek, Davezac, Gabillet, Guerrera, Brouillard, Tondelier, Sermet-Gaudelus, Danel, Lenoir, Daniel, Edelman, Witko-Sarsat: Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Human Polyclonal Coronin 1a Primary Antibody for ICC, IF - ABIN189721
Stray-Pedersen, Jouanguy, Crequer, Bertuch, Brown, Jhangiani, Muzny, Gambin, Sorte, Sasa, Metry, Campbell, Sockrider, Dishop, Scollard, Gibbs, Mace, Orange, Lupski, Casanova, Noroski: Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy. in Journal of clinical immunology 2014
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Human Polyclonal Coronin 1a Primary Antibody for ELISA, IHC - ABIN185063
Ferrari, Langen, Naito, Pieters: A coat protein on phagosomes involved in the intracellular survival of mycobacteria. in Cell 1999
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Human Polyclonal Coronin 1a Primary Antibody for ELISA, WB - ABIN547133
Honoré, Buus, Claësson: Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53. in Proteome science 2008
our findings indicate that coronin 1A is a pivotal component that regulates lysosomal fusion and the secretion pathway in osteoclast-lineage cells and may provide a novel therapeutic target for bone diseases.
these data suggest that coronin 1 is dispensable for mouse NK cell homeostasis and function.
Results suggest the existence of a hitherto unrecognized coronin 1-dependent decision switch early during life that is responsible for peripheral naive T cell survival and homeostasis.
Coro1A represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
the phenotype of T cell-specific Coronin 1a deletion resembles the phenotype observed with conventional (whole body) Coronin 1a knock-out mice. In summary, our findings provide formal proof of the predominant T cell-intrinsic role of Coronin 1A.
phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-Galphas association and the modulation of cAMP production
Authors report that this mutation induces pleiotropic effects in Coro1A protein, including the exacerbation of Coro1A-dependent actin-binding and -bundling activities.
Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation.
An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1.
this work suggests that periods before and after NGF-TrkA-induced Coronin-1 expression (and likely other factors) defines two distinct axon growth states
Absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation.
Our results indicate that Abp1 negatively regulates BCR signaling by coupling actin remodeling to B-cell contraction and activation of inhibitory signaling molecules
Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease.
These results suggest that coronin 1, while important for naive T cell survival, is dispensable for other leukocyte function under inflammatory conditions in vivo.
The results of this study establish Coronin-1 as an essential component of a feedback loop that mediates NGF-TrkA endosome stability, recycling and signaling as a critical mechanism governing developmental competition for survival.
Data suggest that coronin 1 plays a differential role in CD8(+) versus CD4(+) T cell responses and activation.
Coronin 1 is dispensable for antigen processing and presentation by dendritic cells.
These results suggest that Coro1a inhibits autophagosome formation in alveolar macrophages, thereby facilitating Mycobacterium tuberculosis survival within the lung.
Coro1A controls actin association with endocytic organelles, thereby negatively regulating endo-lysosomal delivery, degradation of modified lipoproteins and cholesterol deposition in macrophages.
GRAIL functions via the ubiquitination and degradation of actin cytoskeleton-associated proteins, in particular Arp2/3-5 and coronin 1A
Levels of p21 and p27 were decreased in TACO or pAKT overexpressing HCC due to SKP2 upregulation.
Data suggest that CORO1A plays key role in neuronal signaling; roles of CORO1A in multiple signaling pathways suggest that CORO1A may influence cross talk between key pathways. [REVIEW]
It has been shown that WDR26 promotes Rac1 membrane translocation following a Coro1A-like and Coro1A-dependent mechanism.
Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens.
These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation.
mutatiions result in abnormal T-cells, severe combined immunodeficiency of an epidermodysplasia verruciformis-human papilloma virus mucocutaneous syndrome with B and NK defects and shortened telomeres
Coronin 1 trimerization is essential to promote mycobacterial survival within macrophages
Nox4-mediated redox regulation of PTP1B serves as a modulator, in part through coronin-1C, of the growth and migration of glioblastoma cells.
Results indicate that Coronin1 proteins are at the center of a regulatory hub that coordinates Rac1 activation, effector exchange, and the F-actin organization state during cell signaling.
show a critical role for F-actin deconstruction in cytotoxic function and immunological secretion and identify Coro1A as its mediator
These results demonstrate that coronin-1a is a novel antibody target for clinically isolated syndrome and multiple sclerosis.
Our findings define a new clinical entity of a primary immunodeficiency with increased susceptibility to EBV-induced lymphoproliferation in patients associated with hypomorphic Coronin-1A mutation.
PU.1 and CEBPA are direct transcriptional regulators of CORO1A in acute promyelocytic leukemia and acute myeloid leukemia.
Constitutive turnover of phosphorylation at Thr-412 of p57/coronin-1 regulates its interaction with actin.
Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation
Instead of regulating the F-actin cytoskeleton, coronin 1 functions in balancing pro- and antiapoptotic signals by regulating divalent calcium ion fluxes and calcineurin activation downstream of the T cell receptor.
These results demonstrate that p57/coronin-1 forms homodimers, that the association is mediated by the leucine zipper structure in the C-terminal region, and that it plays a role in the cross-linking of F-actin in the cell.
The leukocyte plasma membrane associates with the actin cytoskeleton through coronin-1.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.
coronin, actin binding protein, 1A
, coronin 1
, coronin 1a
, coronin-like actin binding protein
, coronin-like protein A
, coronin-like protein p57
, tryptophan aspartate-containing coat protein
, actin-binding protein p57
, coronin 1A
, coronin-like protein A (CLIPINA)
, tryptophan aspartate-containing coat protein (TACO)