Coronin 1a antibody (AA 360-461)

Catalog No. ABIN564843

Cited in 3+ publications. The Mouse Monoclonal anti-Coronin 1a antibody (Clone 4G10) (ABIN564843) specifically detects Coronin 1a in WB, ELISA and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Coronin 1a antibody (AA 360-461) (ABIN564843)

Target: Coronin 1a (CORO1A) (Coronin, Actin Binding Protein, 1A (CORO1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Coronin 1a antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4G10

Product Details anti-Coronin 1a Antibody

Binding Specificity: AA 360-461

Purpose: Mouse monoclonal antibody raised against a partial recombinant CORO1A.

Sequence: QEDLYPPTAG PDPALTAEEW LGGRDAGPLL ISLKDGYVPP KSRELRVNRG LDTGRRRAAP EASGTPSSDA VSRLEEEMRK LQATVQELQK RLDRLEETVQ AK

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CORO1A (NP_009005, 360 a.a. ~ 461 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-Coronin 1a antibody (ABIN564843)

Jayachandran, Liu, Bosedasgupta, Müller, Zhang, Moshous, Studer, Schneider, Genoud, Fossoud, Gambino, Khelfaoui, Müller, Bartholdi, Rossez, Stiess, Houbaert, Jaussi, Frey, Kammerer, Deupi et al.: "Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling. ..." in: PLoS biology, Vol. 12, Issue 3, pp. e1001820, (2014) (PubMed).

Federzoni, Humbert, Valk, Behre, Leibundgut, Torbett, Fey, Tschan: "The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients." in: British journal of haematology, Vol. 160, Issue 6, pp. 855-9, (2013) (PubMed).

Moriceau, Kantari, Mocek, Davezac, Gabillet, Guerrera, Brouillard, Tondelier, Sermet-Gaudelus, Danel, Lenoir, Daniel, Edelman, Witko-Sarsat: "Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 11, pp. 7254-63, (2009) (PubMed).

Target Details for Coronin 1a

Target: Coronin 1a (CORO1A) (Coronin, Actin Binding Protein, 1A (CORO1A))

Alternative Name: CORO1A

Background: Full Gene Name: coronin, actin binding protein, 1A
Synonyms: CLABP,CLIPINA,FLJ41407,HCORO1,MGC117380,TACO,p57

Gene ID: 11151

NCBI Accession: NM_007074

Pathways: Regulation of Actin Filament Polymerization