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anti-Human RACGAP1 Antibodies:
anti-Mouse (Murine) RACGAP1 Antibodies:
anti-Rat (Rattus) RACGAP1 Antibodies:
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Human Monoclonal RACGAP1 Primary Antibody for ELISA, WB - ABIN565414
Wolfe, Takaki, Petronczki, Glotzer: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. in PLoS biology 2009
Show all 4 Pubmed References
Human Polyclonal RACGAP1 Primary Antibody for IHC (p), IHC - ABIN257840
Reibel, Dorseuil, Stancou, Bertoglio, Gacon: A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation. in Biochemical and biophysical research communications 1991
Study showed that a subset of epithelial ovarian cancer (EOC) patients have RacGAP1 overexpression which is associated with advanced tumor stages and poor clinical outcomes. Also, RacGAP1 can positively regulate the activation of RhoA (show RHOA Antibodies) and Erk (show EPHB2 Antibodies) proteins, thus up-enhance the migration and invasion process of EOC.
Data show that comparing with Ki-67 (show MKI67 Antibodies) and TOP2A (show TOP2A Antibodies), RacGAP1 allowed for a clearer prognostic statement.
RACGAP1 promotes the metastatic phenotype in uterine carcinosarcoma via a STAT3/survivin signaling pathway.
High RACGAP1 expression is associated with Basal-like Breast Cancers.
Data suggest that MGCRABGAP (show TBC1D21 Antibodies) is involved in mammalian spermiogenesis by modulating RAB10 (show RAB10 Antibodies).
This study showed that the overexpressions of Ki67 (show MKI67 Antibodies), RacGAP1, and TOP2a (show TOP2A Antibodies) affect the prognosis of female breast cancer patients adversely
Data confirmed a strong correlation of AURKA (show AURKA Antibodies) and Wnt (show WNT2 Antibodies)-modulator RACGAP1 gene expression both in the gastric tumor, the tumor-adjacent and the tumor-distant mucosa.
RacGAP1 Is a Novel Downstream Effector of E2F7 (show E2F7 Antibodies)-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
RACGAP1 expression levels in the nucleus and cytoplasm, determined by immunohistochemical staining, predict opposite clinical outcomes and that both could be independent prognostic markers for colorectal cancer.
central spindle assembly and 2 Plk1 (show PLK1 Antibodies)-dependent phosphorylations are required to establish efficient binding of the Ect2 (show ECT2 Antibodies) BRCT in early cytokinesis.
MgcRacGAP SxIP motif is functionally important both for its role in regulating adherens junction structure during interphase and for regulating Rho GTPase activity during cytokinesis.
Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
APC (show APC Antibodies)(CDH1 (show CDH1 Antibodies)) targets MgcRacGAP for destruction in the late M phase.
TLR4 (show TLR4 Antibodies) signaling shapes B cell dynamics via MyD88 (show MYD88 Antibodies)-dependent pathways and Rac (show AKT1 Antibodies) GTPases.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (show AKT1 Antibodies), CDC42 (show CDC42 Antibodies), and RhoG small GTPase activities
Rac (show AKT1 Antibodies) regulates vascular endothelial growth factor (show VEGF Antibodies) stimulated motility
These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases.
alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase (show PIK3CA Antibodies)-Cdc42 (show CDC42 Antibodies)/Rac (show AKT1 Antibodies) pathways may play a role in determining the size and shape of tooth germ
Gab2 (show GAB2 Antibodies) via Shp-2 (show PTPN11 Antibodies) is critical for transmitting signals from Kit Tyr (show TYR Antibodies)(567) to activate the Rac (show AKT1 Antibodies)/JNK (show MAPK8 Antibodies) pathway controlling mast cell proliferation
Data demonstrate that normal cytokinesis in B lymphocytes requires the GAP and NH2 terminal domains but not GAP activity of mgcRacGAP.
Rac (show AKT1 Antibodies) became activated within 2 min after peripheral membrane extensions adhered to new ECM (show MMRN1 Antibodies) islands, and this activation wave propagated outward in an oriented manner as the cells spread from island to island
In vivo cell recordings reveal that gradual loss of wild-type RacGAP1 leads progressively from a failure of abscission, then to cleavage furrow ingression, and finally complete absence of furrow formation. Despite the lack of cytokinesis, gross patterning occurs overtly normally in ogre mutants and cells continue to cycle slowly, some even attaining four or eight nuclei.
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
GTPase activating protein
, male germ cell RacGap
, protein CYK4 homolg
, protein CYK4 homolog
, rac GTPase-activating protein 1
, Rac GTPase-activating protein 1
, Rac GTPase activating protein 1
, rac GTPase-activating protein 1-like