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twinfilin-2 is a protein that is involved in neurite outgrowth
Twf2a-controlled actin rearrangements dampen platelet activation responses.
These data suggest that twinfilin-2a plays a redundant role in cytoskeletal dynamics with the biochemically similar twinfilin-1, which is typically co-expressed in same tissues with twinfilin-2a.
MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear
like Twf1 (show TWF1 Proteins), mouse Twf2 is a filament barbed-end capping protein, and that two tissue-specific and biochemically distinct isoforms are generated from the Twf2 gene through alternative promoter usage
This study suggested that twinfilin 2 plays a role in the regulation of stereocilia elongation by restricting excessive elongation of the shorter row stereocilia thereby maintaining the mature staircase architecture of cochlear hair bundles.
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
, PTK9L protein tyrosine kinase 9-like (A6-related protein)
, protein tyrosine kinase 9-like (A6-related protein)
, twinfilin, actin-binding protein, homolog 2
, twinfilin-1-like protein
, PTK9 protein typrotein tyrosine kinase 9-like (A6-related protein)
, protein tyrosine kinase 9 related protein
, toll-like receptor 9
, twinfilin actin-binding protein 2