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anti-Rat (Rattus) PASK Antibodies:
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PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells.
Mutations that affect PAS domain cause a severe protein trafficking defect and change the interactions with Kv11.1 channels.
The role of PAS kinase in PASsing the glucose signal.
Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion
PASK is involved in the regulation of glucagon secretion by glucose and may be a useful target for the treatment of type 2 diabetes.
Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.
molecular cloning, gene expression, and comparison with mouse protein
Results suggest that elevated glucose concentrations rapidly increase Per-Arnt-Sim kinase activity in pancreatic islet beta cells, followed by up-regulation by glucose of preproinsulin and pancreatic duodenum homeobox 1 gene expression.
identified the multifunctional eukaryotic translation elongation factor eEF1A1 as a novel interaction partner of PASKIN in the nuclei of testis germ cells and in the midpiece of sperm tails
The findings demonstrate cell-autonomous roles for PASK in the control of pancreatic endocrine hormone secretion. Differences between the glycaemic phenotype of global vs cell type-specific null mice suggest important roles for tissue interactions in the control of glycaemia by PASK.
the PAS kinase function could be critical for preserving the nutrient effect on AMP-activated protein kinase and mammalian target of rapamycin/S6K1 pathways and maintain the regulatory role of exendin-4 in food intake
PASK is a key kinase in GLP-1 actions and exerts a coordinated response with the other metabolic sensors.
These data strongly suggest that PASK is required for normal nutrient partitioning and energy homeostasis in the mouse and that this activity is primarily carried out in a cell-autonomous fashion.[Review]
Targeted disruption of the PAS domain serine/threonine kinase was studied.
Paskin gene expression is not induced by glucose in pancreatic beta-cells and glucose-stimulated insulin production is independent of PASKIN.
PASK acts in a cell-autonomous manner to maintain cellular energy homeostasis and is a potential therapeutic target for metabolic disease
Suggest that paskin is involved in the central control of hypoxic ventilation, modulating ventilation in a gender-dependent manner.
PASK is a novel mediator of glucolipotoxicity on the insulin gene in pancreatic beta-cells
This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PAS domain-containing serine/threonine-protein kinase
, PAS domain containing serine/threonine kinase
, PAS domain-containing serine/threonine-protein kinase-like
, per-arnt-sim (PAS) domain kinase