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anti-Human NDEL1 Antibodies:
anti-Rat (Rattus) NDEL1 Antibodies:
anti-Mouse (Murine) NDEL1 Antibodies:
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Human Polyclonal NDEL1 Primary Antibody for ELISA, WB - ABIN449911
Yingling, Youn, Darling, Toyo-Oka, Pramparo, Hirotsune, Wynshaw-Boris: Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. in Cell 2008
Results demonstrate that Ndel1 interacts with Tara to regulate cell movement revealing a novel role of the Ndel1-Tara complex in actin reorganization during cell movement.
results highlight S-Nitrosylation as a key activity-dependent mechanism underlying neonatal brain maturation and suggest that reduction of S-Nitrosylation of NDEL1 acts as a pathological factor mediating neurodevelopmental abnormalities caused by maternal alcohol exposure
disrupting DISC1 (show DISC1 Antibodies)/Ndel1 complex formation prolongs mitotic length and interferes with cell-cycle progression in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and human forebrain organoids
Study showed that Ndel1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to schizophrenia physiopathology
This study observed a significantly increased myelin basic protein (MBP (show MBP Antibodies)) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls.
study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder
The Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia.
Short (DISC)1 splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and phosphodiesterase (PDE)4B proteins, but fully interact with FEZ1 and glycogen synthase kinase 3 (GSK3)beta.
Nudel markedly promotes the HSPC300 (show BRK1 Antibodies)-WAVE2 (show WASF2 Antibodies) interaction.
analysis of mixed NDE1-NDEL1 complexes demonstrates that NDE1 and NDEL1 can interact directly.
This study showed that Ndel1 Maintain Postnatal CA1 (show CA1 Antibodies) Hippocampus Integrity in mice.
Data indicate that NDEL1 is inducibly expressed in the adult nervous system, and signaling via the CREB (show CREB1 Antibodies)/CRE transcriptional pathway is likely involved. Role of NDEL1 in neuronal migration and neurite outgrowth during development raises the interesting prospect that inducible NDEL1 in the mature nervous system could contribute to the well-characterized structural and functional plasticity resulting from repetitive seizures
NDEL1 facilitates the reversal of somatodendritic traansport in the proximal axon.
Results suggest that NDEL1 might interact with DISC1 (show DISC1 Antibodies) to activate ERK (show EPHB2 Antibodies) signaling and function as a potential protective factor during the spontaneous seizure period after pilocarpine-induced status epilepticus
Results show that LIS1 (show PAFAH1B1 Antibodies) acts via the LIS1 (show PAFAH1B1 Antibodies)-NDEL1-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs (show NEU2 Antibodies) with the cell cortex to ensure precise cell division.
Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport.
Expressing a mutant Ndel1 lacking key phosphorylation sites shuts down organelle transport completely in axons.
palmitoylated Ndel1 reduced cytoplasmic dynein (show DYNC1H1 Antibodies) activity as judged by Golgi distribution, VSVG and short microtubule trafficking, transport of endogenous Ndel1 and LIS1 (show PAFAH1B1 Antibodies) from neurite tips to the cell body and neuronal migration
Ndel1b is expressed predominantly in the somites in developing zebrafish.
Nudel/NudE and Lis1 (show PAFAH1B1 Antibodies) promote dynein and dynactin (show DCTN1 Antibodies) interaction in the context of spindle morphogenesis.
The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein
the mechanism of dynein regulation by Nudel and Lis1 (show PAFAH1B1 Antibodies)
Nudel regulates microtubule organization in part by facilitating assembly of the lamin B spindle matrix in a dynein-dependent manner.
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X.
, mitosin-associated protein 1
, mitosin-associated protein MITAP1
, nuclear distribution protein nudE-like 1
, nudE nuclear distribution E homolog-like 1
, nudE nuclear distribution gene E homolog-like 1
, protein Nudel
, LIS1-interacting protein NUDEL
, LIS1-interacting protein NUDEL; endooligopeptidase A
, nuclear distribution gene E-like homolog 1
, nudE nuclear distribution gene E homolog like 1
, endooligopeptidase A protein
, nudE nuclear distribution gene E homolog (A. nidulans)-like 1
, nuclear disribution gene E like
, NudE-like protein 1b
, nuclear distribution protein nudE-like 1-B
, nudE nuclear distribution E homolog (A. nidulans)-like 1
, nuclear distribution protein nudE-like 1-A
, nudE neurodevelopment protein 1-like 1