Browse our anti-CD43 (SPN) Antibodies

Human Sialophorin (SPN) interaction partners

1. CD43 expression was 95.7% in atypical chronic lymphocytic leukemia cases.

2. most non-hematopoietic neoplasms are negative for CD43 expression

3. this study identifies a new signaling pathway for CD43 through the regulation of alternative functions of pyruvate kinase isoform M2, favoring cell survival following activation

4. Forty percent of adenoid cystic carcinomas showed staining for CD43, while no cases of basal cell carcinoma were positive

5. CD43 expression is a novel adverse prognostic factor for patients with diffuse large B-cell lymphomas

6. CD43 polymorphisms are associated with TB susceptibility.

7. Host membrane protein PSGL-1, CD43, and CD44 association with assembling HIV-1 Gag is driven by polybasic sequences present in the cytoplasmic tails of the membrane proteins and in Gag.

8. When used as vaccine in mice, the 2/165 phagotope raised antibodies against the UN1/CD43 antigen, indicating that the 2/165 phagotope mimicked the UN1 antigen structure, and could represent a novel immunogen for cancer immunotherapy

9. CD43 promotes cells transformation by preventing merlin-mediated contact inhibition of growth.

10. We conclude that CD43 is an adverse prognostic marker in DLBCL, and is preferentially expressed in the non-GCB subgroup.

11. CD43 regulates the threshold for T cell activation by targeting Cbl functions.

12. Taken together, these results show that elevated calcium levels induce CD43 capping, and macrophages remove the cells if their nucleolin receptors can bind to the poly-N-acetyllactosaminyl chains of capped CD43.

13. Targeting CD43 in A549 lung cancer cells, increased homotypic adhesion, decreased heterotypic adhesion and transendothelial migration, increased susceptibility to apoptosis and increased vulnerability to lysis by NK cells

14. results suggest that, despite the high CD43 expression in both tumorous and nontumorous Langerhans cells (LCs), the JL1 epitope of CD43 is exposed in immature and neoplastic LCs.

15. Compared to healthy controls, both CD43 mRNA and protein expressions were reduced in T cells from patients with SLE, and were inversely correlated with IgG.

16. CD43 localizes to the nucleus, where it binds chromatin, co-localizes and co-immunoprecipitates with beta-catenin, and enhances the reporter gene expression regulated by beta-catenin

17. The capping of CD43 on the cell surface is a strong signal for phagocytosis that allows phagocytes to differentiate between healthy and apoptotic cells without any additional membrane changes

18. The anti-adhesive function of CD43 in colon carcinoma cells plays a role in the tumorigenesis and metastasis of colorectal carcinoma cells.

19. there exists a negative feedback loop between p53 and CD43: CD43-dependent signaling activates p53, which in turn downregulates the expression of CD43

20. O-glycosylated CD43 and CD45 molecules on T cells regulates cell adhesion and favors the transmission of HTLV-1 from cell to cell.

Mouse (Murine) Sialophorin (SPN) interaction partners

1. Data provide evidence for an important role of CD43 in modulating immune dysregulation and mortality following sepsis.

2. glycosylation status of CD43 protein on leukemia cells is associated with sensitivity to CTL-mediated cytolysis

3. findings demonstrate that CD43 is a major E-selectin ligand in Th17 cells that functions independent of P-selectin glycoprotein ligand-1

4. CD43 may be an important mediator of macrophage lipid homeostasis, thereby affecting macrophage foam cell formation and ultimately atherosclerotic plaque development.

5. We have identified a robust physiologic role for CD43 in a relevant animal model and established an important in vivo function for CD43-dependent regulation of IFN-gamma production.

6. Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism.

7. study found that the M. tuberculosis Cpn60.2 molecular chaperone is the major mycobacterial surface ligand that interacts with CD43 to stabilize the interaction between M. tuberculosis and the macrophage

8. Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice.

9. CD43 engagement and signaling are involved in the costimulatory and antiapoptotic effects of enzymatically inactive mutant trypanosomal trans-sialidase when it binds highly sialylated mucin CD43 on the T cell surface.

10. Cd43 displays dynamic roles in T cell immunity: a positive regulatory role in costimulation and trafficking of T cells to the central nervous system, and a negative regulatory role in the down-modulation of an immune response.

11. Delayed onset of experimental autoimmune encephalomyelitis in CD43-deficient immunized mice and in recipients of adoptively transferred CD43-/- cells is characterized by significant reduction of T cell trafficking to the brain and spinal cord.

12. Exclusion of the CD43 intracellular region from the immunological synapse is required for CD43 regulation of interleukin-2 production.

13. Two functionally distinct populations of small intestinal intraepithelial lymphocytes (IELs) are described that differ according to the expression of a CD43 glycoform.

14. CD43 is involved in the binding, uptake, and subsequent growth of Mycobacterium tuberculosis in murine macrophages and in vivo

15. That CD43 costimulation was responsible for elevated cytokine/chemokine activity was confirmed at the transcriptional level by real-time PCR for IFN-gamma and CCL5, and by ELISA for IFN-gamma.

16. CD43, when modified by a specific set of glycosyltranferases, can function as an E-selectin ligand and therefore potentially mediate activated T cell migration

17. These results characterize an important role for CD43 during the activation and expansion of autoreactive MOG-specific CD8+ T cells.

18. Recruitment of neutrophils and activated T cells in in vivo models is not influenced by CD43 expression.

19. CD43 expressed on activated T cells functions as an E-selectin ligand and thereby mediates T cell migration to inflamed sites, in collaboration with PSGL-1.

20. CD43 functions as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function