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Browse our anti-Exosome Component 3 (EXOSC3) Antibodies

Full name:: anti-Exosome Component 3 Antibodies (EXOSC3)

On www.antibodies-online.com are 57 Exosome Component 3 (EXOSC3) Antibodies from 16 different suppliers available. Additionally we are shipping Exosome Component 3 Proteins (11) and and many more products for this protein. A total of 81 Exosome Component 3 products are currently listed.

Synonyms:: 2310005D06Rik, AI593501, bA3J10.7, hRrp-40, im:7140537, p10, PCH1B, RP11-3J10.8, Rrp40, Rrp40p, zgc:112345

list all antibodies	Gene Name	GeneID	UniProt
	EXOSC3	51010	Q9NQT5
	EXOSC3	66362	Q7TQK4
	EXOSC3	313243
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Most Popular Reactivities for anti-Exosome Component 3 (EXOSC3) Antibodies

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anti-Human Antibodies:

anti-Mouse (Murine) Antibodies:

17 WB Antibodies

anti-Rat (Rattus) Antibodies:

13 WB Antibodies

All available anti-Exosome Component 3 Antibodies

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Relevant Pathways for anti-Exosome Component 3 Antibodies

Production of Molecular Mediator of Immune Response

More product categories related to Exosome Component 3 Antibody

Top referenced anti-Exosome Component 3 Antibodies

Chicken Polyclonal EXOSC3 Primary Antibody for IP, WB - ABIN4309753 : Hsin, Li, Hoque, Tian, Manley: RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells. in eLife 2014 (PubMed)
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Cow (Bovine) Polyclonal EXOSC3 Primary Antibody for WB - ABIN2778686 : Lehner, Sanderson: A protein interaction framework for human mRNA degradation. in Genome research 2004 (PubMed)
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More Antibodies against Exosome Component 3 Interaction Partners

Human Exosome Component 3 (EXOSC3) interaction partners

This is the first case of mitochondrial dysfunction associated with an EXOSC3 mutation, which expands the phenotypic spectrum of pontocerebellar hypoplasia type 1b.
Mutations of EXOSC3/Rrp40p associated with pontocerebellar hypoplasia with progressive cerebral atrophy impact ribosomal RNA processing functions of the exosome in S. cerevisiae.
Knock-down of rbm7, exosc8 and exosc3 in zebrafish showed a common pattern of defects in motor neurons and cerebellum. Our data indicate that impaired RNA metabolism may underlie the clinical phenotype by fine tuning gene expression which is essential for correct neuronal differentiation
EXOSC3 mutations were linked to complicated hereditary spastic paraplegia.
study identified new nonsense and missense mutations in the EXOSC3 gene and showed mutations in this gene are exclusively found in pontocerebellar hypoplasia type 1 patients; there are evident genotype-phenotype correlations in EXOSC3-mediated PCH reflected in clinical outcome, age of death and pons hypoplasia
The same mutation c.92G-->C, p.G31A in EXOSC3 was found in three unrelated Czech Roma patients with Pontocerebellar hypoplasia type 1
The present study indicates that EXOSC3 mutations can underlie clinical phenotype not classifiable as pontocerebellar hypoplasia type 1.
We identified a homozygous mutation [c.395A > C/p.D132A] in EXOSC3 in four patients with muscle hypotonia, developmental delay, spinal anterior horn involvement, and prolonged survival, consistent with the "mild PCH1 phenotype".
Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

Mouse (Murine) Exosome Component 3 (EXOSC3) interaction partners

EXOSC3 mutations account for 30%-40% of patients with PCH1 with variability in survival and clinical severity that is correlated with the genotype.

Zebrafish Exosome Component 3 (EXOSC3) interaction partners

Knock-down of rbm7, exosc8 and exosc3 in zebrafish showed a common pattern of defects in motor neurons and cerebellum. Our data indicate that impaired RNA metabolism may underlie the clinical phenotype by fine tuning gene expression which is essential for correct neuronal differentiation

Exosome Component 3 (EXOSC3) Antigen Profile

Antigen Summary

This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternative names and synonyms associated with Exosome Component 3 (EXOSC3)

exosome component 3 (EXOSC3) antibody
exosome component 3 L homeolog (exosc3.L) antibody
exosome component 3 (Exosc3) antibody
exosome component 3 (exosc3) antibody

2310005D06Rik antibody
AI593501 antibody
bA3J10.7 antibody
hRrp-40 antibody
im:7140537 antibody
p10 antibody
PCH1B antibody
RP11-3J10.8 antibody
Rrp40 antibody
Rrp40p antibody
zgc:112345 antibody

Protein level used designations for EXOSC3

exosome complex exonuclease RRP40 , exosome complex component RRP40 , exosome component 3 , ribosomal RNA-processing protein 40

GENE ID	SPECIES
423626	Gallus gallus
465105	Pan troglodytes
716347	Macaca mulatta
100152421	Sus scrofa
734370	Xenopus laevis
51010	Homo sapiens
481616	Canis lupus familiaris
533245	Bos taurus
66362	Mus musculus
313243	Rattus norvegicus
565000	Danio rerio

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