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Role of CD1d- and MR1-Restricted T Cells in Asthma.
Human mucosal-associated invariant T cells possess capacity for B cell help via MR1-mediated immunoglobulins production.
Early endosomal TLR9 activation is important for MR1-mediated bacterial antigen presentation in B cells.
Polymorphism in MR1 gene is associated with susceptibility to tuberculosis.
we have shown that MR1-mediated MAIT cell activation is tightly regulated at several levels. Efficient MR1-mediated MAIT cell activation requires both intact bacteria to access an acidified endolysomal compartment and activation of the APC through NF-kappaB or interferon signaling pathways.
results suggest that high expression of MR-1 is involved in hepatocellular carcinoma progression
Data show that the major histocompatibility complex, class I-related protein (MR1) antigen presentation is characterized by a rapid 'off-on-off' mechanism that is strictly dependent on antigen availability.
endosome-mediated trafficking of MR1 allows for selective sampling of the intracellular environment
Studies indicate that the antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells.
Data indicate that high expression of CD26 ia a specific markers to define major histocompatibility complex, class I-like sequence protein MR1-restricted mucosa-associated invariant T (MAIT) cells.
Mucosal-associated invariant T cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes.
[review] Mucosal-associated invariant T-cell (MAIT) T-cell antigen receptor recognizes riboflavin and folic acid metabolites bound by MR1 in a conserved docking mode and thus acts like a pattern recognition receptor.
MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells.
A novel MR1B isoform probably plays a physiological role complementary to MR1A with respect to mucosal-associated invariant T cells development and/or function.
Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress.
metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance; as many vitamin biosynthetic pathways are unique to bacteria and yeast, data suggest that MAIT cells use these metabolites to detect microbial infection
Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation
Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface.
fact that MR1 seems mainly intracellular might offer clues as to the process, given the precedence in other class I molecules
MR1 molecules can associate with the peptide-loading complex and can be detected at low levels at the surface of transfected cells.
Here the authors demonstrate that major histocompatibility complex class I deficiency results in significant dendritic atrophy along with an increase in thin dendritic spines and a reduction in stubby spines in the hippocampus of aged (12 month old) mice.
differential contribution of particular amino acids to the MAIT TCR-MR1 interaction based upon the presence of bacteria
The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis.
Data suggest that constitutive expression of MR1 may be detrimental for maintenance of immune homeostasis in the gut and/or detection of pathogenic bacteria in mucosal tissues.
The study demonistrated that the enhanced neuronal MHCI expression as a beneficial factor for promoting recovery of locomotor function after spinal cord injury.
Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice.
MR1 protein can associate with beta(2)-microglobulin
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Analysis of murine MR1 expressed in a murine cell line reveals that MR1 associates with the peptide-loading complex, indicating that MR1 uses the same cellular assembly machinery as do classical class I molecules.
MR1 has an antigen presentation function
HA peptides are expressed by EGCs and recognized by CD8 T cells that express a T-cell receptor (TCR) specific for Kd:HA512-520 (CL4) or CD4 T cells that express a TCR specific for IEd:HA107-119 (6.5), respectively.
MR1 traffics through endocytic compartments, thereby allowing mucosal-associated invariant T cells to sample both endocytosed and endogenous antigens.
the presentation pathway of MR1 to MAIT cells is highly evolutionarily conserved
non-MHC-linked class I-related gene
MHC Rfp-Y class I alpha chain
, MHC class I-related protein
, major histocompatibility complex class I-related gene protein
, major histocompatibility complex class I-related protein variant 550
, major histocompatibility complex, class I-related
, Major histocompatibility complex class I-related gene protein
, MHC class I-like antigen MR-1
, MHC class I-related gene protein
, MHC class-I related-gene protein
, class I histocompatibility antigen-like protein
, major histocompatibility complex, class I-like sequence
, MCH class I
, histocompatibility-2 complex class 1-like sequence
, MHC class I-like sequence
, MHC class I related protein, MR1B1 isoform