Browse our anti-P2RX7 (P2RX7) Antibodies

Zebrafish Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

1. Blockade of the P2X7 receptor reduces cyst formation via ERK (show MAPK1 Antibodies)-dependent pathways in a zebrafish model of polycystic kidney disease.

Human Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

1. Increased expression of P2X7R in peripheral blood mononuclear cells from patients with rheumatoid arthritis.P2X7R role in th17 cells differentiation.

2. results show that P2X7 is a scavenger receptor with important function in the CNS but its phagocytic function has features distinct from its pore function. Both P2X7 pore formation and P2X7-mediated phagocytosis should be considered in the design of new P2X7 antagonists for the treatment of CNS diseases.

3. This pathway provides new insight into factors that increase dynamic blebbing and identifies new targets, such as P2X7, that can be used to improve the culture of cells with therapeutic potential.

4. a major role for P2X7R and P2Y11R in ATP-mediated inhibition of tumor-derived endothelial cell migration, is reported.

5. we suggested that P2X7R and NLRP3 (show NLRP3 Antibodies) inflammasome are over-expressed in HNSCC and that the degree of expressional level may represent prognosis of patients.

6. To investigate the correlation between P2X7R, NLRP3 (show NLRP3 Antibodies) and cell growth, NLRP3 (show NLRP3 Antibodies) was silenced in THP-1 (show GLI2 Antibodies) cells, a leukemic cell line that natively expresses both NLRP3 (show NLRP3 Antibodies) and P2X7R. NLRP3 (show NLRP3 Antibodies) silencing enhanced P2X7R expression and promoted growth. On the contrary, NLRP3 (show NLRP3 Antibodies) overexpression caused accelerated apoptosis.

7. Genetic polymorphisms of the P2X7 gene associated with susceptibility to and prognosis of pulmonary tuberculosis.

8. The results suggest that although the 1068 G>A polymorphism of the P2RX7 gene is associated with an increased beta-cell function and IL-1Ra (show IL1RN Antibodies) release in type 2 diabetes patients, the glycemic control is not significantly affected by the presence of this SNP.

9. These data suggest that P2X7R activation may contribute to the high prevalence of kidney disease found in diabetics.

10. In conclusion, the results suggest that P2X7R may promote IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies) and MCP-1 (show CCL2 Antibodies) production and secretion and contribute to the invasion and adhesion of craniopharyngiomas to the surrounding tissue.

Cow (Bovine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

1. For the inflammasome-dependent IL-1beta (show IL1B Antibodies) release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta (show IL1B Antibodies) release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.

Mouse (Murine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

1. P2X7R role in th17 cells differentiation.

2. Studies indicate the role of P2X7R (purinergic 2X7 receptor) and NLRP3 (show NLRP3 Antibodies) (NACHT, LRR, and PYD domains-containing protein 3 (show HSPB3 Antibodies)) inflammasome activation in the process of pancreatic fibrosis in chronic pancreatitis (CP) and suggest that blockade of P2X7R-NLRP3 (show NLRP3 Antibodies) inflammasome signaling pathway may represent a therapeutic strategy for CP and its fibrotic process.

3. CD39 (show ENTPD1 Antibodies) expression in macrophages limits P2X7-mediated pro-inflammatory responses, scavenging extracellular ATP and ultimately generating adenosine. CD39 (show ENTPD1 Antibodies) genetic deletion exacerbates sepsis-induced experimental liver injury.

4. P2X7 receptor signaling is involved in neuronal cell death after axonal injury, being P2X7 receptor antagonism a potential therapeutic strategy.

5. Results show P2xr7-dependent synaptic alterations in the learned helplessness animal model of depression, suggesting a potential structural correlate of the antidepressant effect of genetic deletion of P2rx7.

6. P2X7 receptor deficient mice (P2rx7-/-), the social interactions were increased, whereas the PCP (show BMP1 Antibodies) induced hyperlocomotion and stereotype behavior were alleviated. The selective P2X7 receptor antagonist JNJ-47965567 partly replicated the effect of gene deficiency on PCP (show BMP1 Antibodies)-induced behavioral changes and counteracted PCP (show BMP1 Antibodies)-induced social withdrawal.

7. the data from P2rx7(-/-) mice indicate that the retinoic acid-P2X7 pathway is important in preventing aberrant buildup of activated T cells

8. These data suggest that P2X7 receptor plays a key role in parasite control by regulating T effector cells and inflammation during L. amazonensis infection

9. Heterozygous mice for the P2X7 receptor have impaired receptor function and show sleep disturbances.

10. we showed that the proinflammatory P2X7 receptor is extremely important on the immune response regulation to control parasite burden of virulent T. gondii infection and its associated tissue destruction.