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anti-Human TAP1 Antibodies:
anti-Mouse (Murine) TAP1 Antibodies:
anti-Rat (Rattus) TAP1 Antibodies:
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Human Polyclonal TAP1 Primary Antibody for IHC (p), ELISA - ABIN545756
Tang, Freedman, Allen, Karita, Musonda, Braga, Margolick, Kaslow: TAPI polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies. in Human immunology 2001
Show all 3 Pubmed References
Human Polyclonal TAP1 Primary Antibody for IF (cc), IF (p) - ABIN680728
Stettner, Lohmann, Wolffram, Weinberger, Dehmel, Hartung, Mausberg, Kieseier: Interleukin-17 impedes Schwann cell-mediated myelination. in Journal of neuroinflammation 2014
Human Monoclonal TAP1 Primary Antibody for ICC, IF - ABIN108594
Kim, Kataoka, Dreyfuss: Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. in Science (New York, N.Y.) 2001
TAP polymorphisms have no or limited effect on peptide transport or MHC class I expression.
Our finding suggested that TAP1-rs1135216, TAP1-rs4148873, TAP2-rs2228396, TAP2-rs241447 and TAP2-rs4148873 might not be involved in cancer risk, but the T allele of TAP2-rs4148876 might be a potential biomarker for judging cancer risk [review, meta-analysis]
In a meta-analyses of 6 studies with 415 cases and 659 controls, a significant association was found between TAP1-333Val, TAP1-637Gly, and TAP2-565Thr and ankylosing spondylitis compared with combined control group.
Both TAP1 and TAP2 overexpression in breast cancer might be an indicator of an aggressive breast tumor
The structure shows that herpes simplex virus ICP47 traps human TAP in an inactive conformation distinct from the normal transport cycle.
PSMB8 rs2071464 was associated with generalized and active vitiligo from Gujarat whereas TAP1 rs1135216 showed no association. The down-regulation of PSMB8 in patients with risk genotype 'CC' advocates the vital role of PSMB8 in the autoimmune basis of vitiligo.
Study compared the biochemical properties of the nucleotide-binding domains (NBD) of human and rat TAP1; suggests that although the D-helix sequence is not conserved in ABC transporters, its precise positioning within the NBD structure has a critical role in NBD dimerization.
Significant associations between sorafenib exposure and the studied polymorphisms were observed for ABCB2
this study shows that TAP1 plays a novel role in the negative regulation of virus-triggered NF-kappaB signaling and the innate immune response by targeting the TAK1 complex
there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients
The disruption of TAP1 and TAPBP generates pluripotent embryonic stem cells with reduced immunogenicity.
TAP1/2 gene polymorphisms might be associated with pulmonary tuberculosis susceptibility among patients in Zahedan, southeast Iran.
The results suggest an association between a TAP1 promoter SNP (rs2071480) and susceptibility to alopecia areata in a Korean population.
IFNalpha upregulates TAP1 expression in peripheral blood mononuclear cells (PBMCs) of patients with malignant melanoma receiving adjuvant high-dose immunotherapy.
cryo-electron microscopy structure of human TAP in complex with its inhibitor ICP47, a small protein produced by the herpes simplex virus I
this ultrasensitive method for the first time permits quantification of TAP activity under close to physiological conditions in scarce primary cell subsets such as antigen cross-presenting dendritic cells.
PSF1 expression correlates with a more aggressive phenotype as well as worse prognosis in hepatocellular carcinoma patients.
PSF1 is expressed in high-grade prostate cancer and may be a useful biomarker to identify patients with a poor prognosis at the time of diagnosis
Studies indicate that ABC transporters associated with antigen processing TAP1/2 (ABCB2/3) is a crucial element of the adaptive immune system.
None of TAP1 alleles showed a signi fi cant di ff erence in phenotype frequency between pulmonary tuberculosis and controls, and among subgroups of pulmonary tuberculosis.
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
It transport class I antigens to cell surface of CD8 positive lymphocytes which have a vital role in liver inflammation like fructose-induced steatosis.
Knocking out Tap1 abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits.
Apoe(-/-)Tap1(-/-) mice develop atherosclerosis equal to Apoe(-/-) mice, indicating a minor role for CD8(+) T cells and TAP1-dependent antigen presentation in the disease process.
Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation.
Our data suggest that the normal influx of TAP-transported peptides in the ER during routine processing creates an efficient barrier for peptides from alternative processing routes.
A complete overview is presented of the applicability of herpesvirus-encoded TAP and tapasin inhibitors in mouse cells of different genetic background.
downregulation of expression in PBMC of chronic hepatitis B patients
Our results do not support a role for MHC class I (TAP1) in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons.
a new role for mouse TAP2 in stabilizing TAP1 protein expression is shown using the Jasmine strain; Jasmine has an A to C transversion in exon 5 of TAP2, resulting in a threonine to proline substitution at position 293 of the protein.
Allergen-specific CD8+ T cells were recruited to and specifically activated in the lungs of sensitized animals after allergen-aerosol challenge, a process that was dependent on a functional TAP complex
MHC conformational changes, revealed at molecular level, may influence the immunogenicity
Macrophages cross-presented p33-VLP normally in the absence of TAP. The TAP-dependent pathway of cross-presentation is therefore confined to DC while both macrophages and DC harbor the TAP-independent pathway.
A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression
Tap1 is required for class I major histocompatibility complex (MHC-I) to bind endoplasmic reticulum-derived stabilizing peptides to achieve stability needed for alternate MHC-I processing via peptide exchange in acidic vacuolar processing compartments.
Presensitization of TAP1-/- mice with H-2K(b) peptides accelerated the rejection of C57BL/6 (H-2(b)) skin grafts.
PSF1 is required for early embryogenesis
These data suggest that PSF1 and SLD5 may cooperate in the proliferation of immature cell populations.
role for TAP-1 in the induction of IFN-gamma-producing NK (naatural killer) cells and demonstration that NK cell licensing can influence host resistance to infection.
regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport by ERK map kinases requires TAP-NxT1 binding and the AU-rich element
data indicate that TAP1 expression is increased by demethylation of promoter CpG islands, with CpG_4, CpG_13 and CpG_15 implicated as the critical regulatory sites
The TAP1 mRNA levels in GG genotype were significantly higher than that in the other two genotypes, with significant differences in the liver, lung, kidney, thymus, lymph node, duodenum and jejunum tissues.
These analyses showed that the TAP1 gene, which was related to MHC I immune regulation, had a stable and low expression level in unweaned stages; however, its expression increased in the postweaning stages.
The TAP1 gene is associated with swine immune responses.
Two splice variants of TAP1 were found.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
ABC transporter, MHC 1
, ATP-binding cassette sub-family B member 2
, ATP-binding cassette, sub-family B (MDR/TAP), member 2
, antigen peptide transporter 1
, peptide supply factor 1
, peptide transporter PSF1
, peptide transporter TAP1
, peptide transporter involved in antigen processing 1
, really interesting new gene 4 protein
, transporter associated with antigen processing
, transporter, ATP-binding cassette, major histocompatibility complex, 1
, transporter associated with antigen processing 1a
, transporter associated with antigen presentation 1
, transporter associated with antigen processing 1
, transporter 1 ATP-binding cassette sub-family B
, ABC transporter, MHC, 1
, ATP dependent transport protein family member
, ATP-binding cassette transporter, major histocompatibility complex, 1
, histocompatibility antigen modifier 1
, transporter 1, ABC (ATP binding cassette)
, transporter, ABC, MHC, 1
, transporter 1 ABC (ATP binding cassette)