TAP1 antibody (Middle Region)

Catalog No. ABIN2781498

Product Details anti-TAP1 Antibody

Target: TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LVTFVLYQMQ FTQAVEVLLS IYPRVQKAVG SSEKIFEYLD RTPRCPPSGL

Predicted Reactivity: Cow: 92%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against TAP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TAP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 808 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TAP1

Target: TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))

Alternative Name: TAP1 (TAP1 Products)

Synonyms: ABC17 antibody, ABCB2 antibody, APT1 antibody, D6S114E antibody, PSF-1 antibody, PSF1 antibody, RING4 antibody, TAP1*0102N antibody, TAP1N antibody, abc17 antibody, abcb2 antibody, apt1 antibody, psf1 antibody, ring4 antibody, tap1a antibody, tap1n antibody, Abcb2 antibody, Ham-1 antibody, Ham1 antibody, MTP1 antibody, TAP antibody, Tap-1 antibody, Y3 antibody, Cim antibody, transporter 1, ATP binding cassette subfamily B member antibody, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) L homeolog antibody, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) antibody, TAP1 antibody, tap1.L antibody, Tap1 antibody

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). TAP1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. TAP1 is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble.The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC17, ABCB2, APT1, D6S114E, FLJ26666, FLJ41500, PSF1, RING4, TAP1*0102N, TAP1N, PSF-1
Protein Interaction Partner: UBC, MUL1, TDP2, SFXN1, GADD45GIP1, MRPL40, MCAT, SRSF3, SDHA, ABCD3, CYC1, PSMB8, TAPBP, TAP2, HLA-A, PDIA3, CALR, B2M, PDIA2, KRTAP4-12, MDFI, PSMB5, HLA-F, HLA-G, ESR1, COPG1, COPB1,
Protein Size: 808

Molecular Weight: 87 kDa

Gene ID: 6890

NCBI Accession: NM_000593, NP_000584

UniProt: Q03518

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process