Browse our Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Proteins (TNFSF13)

Full name:: Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Proteins (TNFSF13)

On www.antibodies-online.com are 42 Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) Proteins from 12 different suppliers available. Additionally we are shipping Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Antibodies (202) and Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Kits (42) and many more products for this protein. A total of 297 Tumor Necrosis Factor (Ligand) Superfamily, Member 13 products are currently listed.

Synonyms:: 2310026N09Rik, ANP32B, april, CD256, SLAN, TALL-2, Tall2, tnf13, TNLG7B, TRDL-1, Trdl1, ZTNF2

list all proteins	Gene Name	GeneID	UniProt
	TNFSF13	8741	O75888
	TNFSF13	69583	Q9D777
	TNFSF13	287437
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Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Proteins (TNFSF13) by Origin

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Top referenced Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Proteins

Human TNFSF13 Protein expressed in HEK-293 Cells - ABIN1344412 : Litinskiy, Nardelli, Hilbert, He, Schaffer, Casali, Cerutti: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. in Nature immunology 2002 (PubMed)
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Human TNFSF13 Protein expressed in HEK-293 Cells - ABIN1344410 : Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. in PLoS ONE 2012 (PubMed)
Human TNFSF13 Protein expressed in Wheat germ - ABIN1323221 : Chihara, Aranami, Sato, Miyazaki, Miyake, Okamoto, Ogawa, Toda, Yamamura: Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)

More Proteins for Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) interaction partners

TNFSF13, SPATC1L, SLC22A25 and SALL4 (show SALL4 Proteins) may thus be novel susceptibility loci for atrial fibrillation in the Japanese population
The results suggest that increased levels of BAFF (show TNFSF13B Proteins) and APRIL produced in the central nervous system may influence the development of anti-neutrophil cytoplasmic antibody-hypertrophic pachymeningitis.
The genetic variations and gene expression level of TNFSF13 are associated with the susceptibility and severity of IgA nephropathy in a Han Chinese population.
APRIL but not BLyS (show TNFSF13B Proteins) promotes IL-10 (show IL10 Proteins) production by CpG-activated B cells and enhances the regulatory role of B cells on T cells.
BCMA (show TNFRSF17 Proteins) has other contributors for ligands binding except DxL motif. The affinity of BCMA (show TNFRSF17 Proteins) for APRIL higher than for BAFF (show TNFSF13B Proteins) may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
ApoE-/-APRIL-Tg mice have increased oxLDL-specific serum IgM levels, potentially mediated via an increase in B1a lymphocytes
Results showed that chemokine (show CCL1 Proteins)-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression.
This study showed that both BAFF (show TNFSF13B Proteins) and APRIL levels were increased in CSF (show CSF2 Proteins) of patients with anti-NMDAR (show GRIN1 Proteins) encephalitis.
New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA (show TNFRSF17 Proteins) and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM.
Urinary APRIL (uAPRIL) and BAFF (show TNFSF13B Proteins) (uBAFF) levels were raised significantly in AN.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) interaction partners

p40, a Lactobacillus rhamnosus-derived protein upregulates EGFR-dependent APRIL expression in intestinal epithelial cells, which may contribute to promoting IgA production
this study identifies APRIL as a new target involved in B-cell activation (show BLNK Proteins), in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice
this is the first study to implicate the APRIL signal transduction pathway in the pathogenesis of nephrogenic IgA production. Moreover, our findings identify APRIL as a potential target of therapy.
the elevated presence of APRIL and BLyS (show TNFSF13B Proteins) in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL (show TNFSF11 Proteins)-expressing B cells/plasma cells.
B cell activating factor (BAFF (show TNFSF13B Proteins)) and a proliferation inducing ligand (APRIL) mediate CD40 (show CD40 Proteins)-independent help by memory CD4 (show CD4 Proteins) T cells in transplantations.
Heteromers consisting of one BAFF (show TNFSF13B Proteins) and two APRIL bind to receptor TACI (show TNFRSF13B Proteins), BCMA (show TNFRSF17 Proteins) but not to BAFFR (show TNFRSF13C Proteins).
Immunization of mice with a DNA vaccine encoding BAFF (show TNFSF13B Proteins) or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env (show ERVW-1 Proteins) gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses.
APRIL selectively enhances axonal growth by activating ERK signaling and PI3-kinase/Akt/GSK-3beta signaling.
Data indicate that APRIL expression accelerates the onset of TCL1 (show TCL1A Proteins)-driven leukemia formation mainly through TACI (show TNFRSF13B Proteins) activation.
The ability of TACI (show TNFRSF13B Proteins)-Fc to activate reverse signalling through BAFF (show TNFSF13B Proteins) and APRIL, was investigated.

Rabbit Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) interaction partners

Although proliferation-inducing ligand TNFSF13/APRIL expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (show GUSB Proteins)-associated lymphoid tissue.
Cloning and expression analysis of a proliferation-inducing ligand (APRIL) provides the basis for investigation of its role in regulating rabbit B-lymphocyte (show AKAP17A Proteins) development and immune responses.

Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Alternative names and synonyms associated with Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13)

TNF superfamily member 13 (TNFSF13)
tumor necrosis factor (ligand) superfamily, member 13 (Tnfsf13)
acidic leucine-rich nuclear phosphoprotein 32 family member B (LOC494442)
tumor necrosis factor (ligand) superfamily, member 13 (tnfsf13)
TNF superfamily member 13 (Tnfsf13)
tumor necrosis factor (ligand) superfamily, member 13 (TNFSF13)

2310026N09Rik protein
ANP32B protein
april protein
CD256 protein
SLAN protein
TALL-2 protein
Tall2 protein
tnf13 protein
TNLG7B protein
TRDL-1 protein
Trdl1 protein
ZTNF2 protein

Protein level used designations for TNFSF13

TNF- and APOL-related leukocyte expressed ligand 2 , a proliferation-inducing ligand , tumor necrosis factor ligand superfamily member 13 , tumor necrosis factor-like protein ZTNF2 , tumor necrosis factor-related death ligand-1 , SLAN protein , Acidic leucine-rich nuclear phosphoprotein 32 family member B , TNF superfamily member 13 , A proliferation-inducing ligand , tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein , tumor necrosis factor (ligand) superfamily, member 13 , tumor necrosis factor superfamily member 13 , proliferation-inducing ligand , tumor necrosis factor ligand 7B

GENE ID	SPECIES
8741	Homo sapiens
69583	Mus musculus
494442	Ovis aries
100127162	Sus scrofa
100136706	Oncorhynchus mykiss
287437	Rattus norvegicus
538567	Bos taurus
100196575	Salmo salar
100434469	Pongo abelii
100551504	Pan troglodytes
100551507	Macaca mulatta
100551510	Callithrix jacchus
100551512	Monodelphis domestica
100568281	Canis lupus familiaris
100860886	Capra hircus
100147233	Equus caballus
100126074	Oryctolagus cuniculus

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Show all Tumor Necrosis Factor (Ligand) Superfamily, Member 13 Proteins (TNFSF13) with Pubmed References