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Human TNFSF13 Protein expressed in HEK-293 Cells - ABIN1344412
Litinskiy, Nardelli, Hilbert, He, Schaffer, Casali, Cerutti: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. in Nature immunology 2002
Show all 9 Pubmed References
Human TNFSF13 Protein expressed in HEK-293 Cells - ABIN1344425
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. in PLoS ONE 2012
Human TNFSF13 Protein expressed in Wheat germ - ABIN1323221
Chihara, Aranami, Sato, Miyazaki, Miyake, Okamoto, Ogawa, Toda, Yamamura: Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. in Proceedings of the National Academy of Sciences of the United States of America 2011
APRIL but not BLyS (show TNFSF13B Proteins) promotes IL-10 (show IL10 Proteins) production by CpG-activated B cells and enhances the regulatory role of B cells on T cells.
BCMA (show TNFRSF17 Proteins) has other contributors for ligands binding except DxL motif. The affinity of BCMA (show TNFRSF17 Proteins) for APRIL higher than for BAFF (show TNFSF13B Proteins) may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
ApoE-/-APRIL-Tg mice have increased oxLDL-specific serum IgM levels, potentially mediated via an increase in B1a lymphocytes
Results showed that chemokine (show CCL1 Proteins)-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression.
This study showed that both BAFF (show TNFSF13B Proteins) and APRIL levels were increased in CSF (show CSF2 Proteins) of patients with anti-NMDAR (show GRIN1 Proteins) encephalitis.
New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA (show TNFRSF17 Proteins) and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM.
Urinary APRIL (uAPRIL) and BAFF (show TNFSF13B Proteins) (uBAFF) levels were raised significantly in AN.
Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.
Recombinant human APRIL (rhAPRIL) could rescue HCC (show FAM126A Proteins) cell proliferation inhibited by miR (show MLXIP Proteins)-383.
Host-derived proteins pp32 and APRIL interact with a free form of influenza virus RNA-dependent RNA polymerase and preferentially upregulates viral RNA synthesis rather than cRNA synthesis.
p40, a Lactobacillus rhamnosus-derived protein upregulates EGFR-dependent APRIL expression in intestinal epithelial cells, which may contribute to promoting IgA production
this study identifies APRIL as a new target involved in B-cell activation (show BLNK Proteins), in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice
this is the first study to implicate the APRIL signal transduction pathway in the pathogenesis of nephrogenic IgA production. Moreover, our findings identify APRIL as a potential target of therapy.
the elevated presence of APRIL and BLyS (show TNFSF13B Proteins) in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL (show TNFSF11 Proteins)-expressing B cells/plasma cells.
B cell activating factor (BAFF (show TNFSF13B Proteins)) and a proliferation inducing ligand (APRIL) mediate CD40 (show CD40 Proteins)-independent help by memory CD4 (show CD4 Proteins) T cells in transplantations.
Heteromers consisting of one BAFF (show TNFSF13B Proteins) and two APRIL bind to receptor TACI (show TNFRSF13B Proteins), BCMA (show TNFRSF17 Proteins) but not to BAFFR (show TNFRSF13C Proteins).
Immunization of mice with a DNA vaccine encoding BAFF (show TNFSF13B Proteins) or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env (show ERVW-1 Proteins) gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses.
APRIL selectively enhances axonal growth by activating ERK signaling and PI3-kinase/Akt/GSK-3beta signaling.
Data indicate that APRIL expression accelerates the onset of TCL1 (show TCL1A Proteins)-driven leukemia formation mainly through TACI (show TNFRSF13B Proteins) activation.
The ability of TACI (show TNFRSF13B Proteins)-Fc to activate reverse signalling through BAFF (show TNFSF13B Proteins) and APRIL, was investigated.
Although proliferation-inducing ligand TNFSF13/APRIL expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (show GUSB Proteins)-associated lymphoid tissue.
Cloning and expression analysis of a proliferation-inducing ligand (APRIL) provides the basis for investigation of its role in regulating rabbit B-lymphocyte (show AKAP17A Proteins) development and immune responses.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
TNF- and APOL-related leukocyte expressed ligand 2
, a proliferation-inducing ligand
, tumor necrosis factor ligand superfamily member 13
, tumor necrosis factor-like protein ZTNF2
, tumor necrosis factor-related death ligand-1
, SLAN protein
, Acidic leucine-rich nuclear phosphoprotein 32 family member B
, TNF superfamily member 13
, A proliferation-inducing ligand
, tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein
, tumor necrosis factor (ligand) superfamily, member 13
, tumor necrosis factor superfamily member 13
, proliferation-inducing ligand
, tumor necrosis factor ligand 7B