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anti-Mouse (Murine) CTGF Antibodies:
anti-Human CTGF Antibodies:
anti-Rat (Rattus) CTGF Antibodies:
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Human Polyclonal CTGF Primary Antibody for IHC (p), WB - ABIN3042771
Li, Zhang, Wang, Zheng, Chen: Nicousamide blocks the effects of advanced glycation end products on renal cells. in European journal of pharmacology 2012
Show all 8 Pubmed References
Human Polyclonal CTGF Primary Antibody for ICC, IF - ABIN152147
Alfaro, Deskins, Wallus, DasGupta, Davidson, Nanney, A Guney, Gannon, Young: A physiological role for connective tissue growth factor in early wound healing. in Laboratory investigation; a journal of technical methods and pathology 2012
Show all 4 Pubmed References
Human Polyclonal CTGF Primary Antibody for IF (p), IHC (p) - ABIN672636
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. in International journal of clinical and experimental pathology 2014
Show all 3 Pubmed References
Human Polyclonal CTGF Primary Antibody for ELISA, WB - ABIN2473120
Sánchez de la Muela, Zudaire, Robles, Rosell, Aguera, De Castro, Isa, Berián: [Survival analysis in renal cell carcinoma with invasion of the vena cava]. in Actas urologicas españolas 1991
Show all 3 Pubmed References
Human Polyclonal CTGF Primary Antibody for Func, IF - ABIN2473119
Moussad, Brigstock: Connective tissue growth factor: what's in a name? in Molecular genetics and metabolism 2000
Show all 3 Pubmed References
Human Polyclonal CTGF Primary Antibody for IHC, IHC (p) - ABIN4300783
Livingston, Ding, Huang, Hill, Yin, Dong: Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. in Autophagy 2016
Human Monoclonal CTGF Primary Antibody for ELISA, WB - ABIN514745
Polacek, Bruun, Johansen, Martinez: Comparative Analyses of the Secretome from Dedifferentiated and Redifferentiated Adult Articular Chondrocytes. in Cartilage 2015
Human Polyclonal CTGF Primary Antibody for IHC (p), WB - ABIN672638
Gendron, Lemay, Lecours, Perreault-Vallières, Huppé, Bossé, Blanchet, Dion, Marsolais: FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury. in Pulmonary pharmacology & therapeutics 2017
Human Polyclonal CTGF Primary Antibody for WB - ABIN223605
Chen, Lan, Zhou, Li, Zhang, Zhang, Yang, Li: Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. in Planta medica 2011
Data (including data from studies using transgenic mice) suggest that Ctgf secreted from vascular endothelium in pancreas plays critical role in up-regulation of insulin (show INS Antibodies) secretion in pancreatic beta-cells during pregnancy; here, pregnant mice with global Ctgf haplo-insufficiency (heterozygous for loss-of-function mutation) (a) exhibit impairment in maternal beta-cell proliferation and (b) develop gestational diabetes.
The data demonstrate that MMP13 (show MMP13 Antibodies) and CTGF play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.
p-SMAD2 (show SMAD2 Antibodies)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (show TGFB1 Antibodies) induced CTGF exp p-SMAD2 (show SMAD2 Antibodies)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (show TGFB1 Antibodies) induced CTGF expression during tooth development.
Ctgf is the direct target gene of SOX9 (show SOX9 Antibodies) in chondrocytes and nucleus pulposus cells.
As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiog (show VEGFC Antibodies)enesis through regulation of, and direct interaction with, VEGF-C.
CTGF and BMP2 (show BMP2 Antibodies) are induced following myocardial ischemia in mice and humans.
this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin (show CTNNB1 Antibodies) overexpression and preventing podocyte EMT (show ITK Antibodies), which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN.
LPA (show LPA Antibodies)-LPA1 (show LPAR1 Antibodies) signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results.
CTGF role in cardiac fibrosis. Long noncoding RNA H19 (show NCKAP1 Antibodies) mediates CTGF expression.
This study study discovered a positive feedback loop between CTGF and CCL18 (show CCL18 Antibodies) in hepatocellular carcinoma metastasis.
Serum connective tissue growth factor (CTGF) is a promising diagnostic biomarker for rheumatoid arthritis (RA).
Connective tissue growth factor (CTGF) is an important mediator of renal allograft fibrosis, and urinary CTGF (CTGFu) levels correlate with the development of allograft interstitial fibrosis. We evaluated the predictive value of CTGF protein expression in 160 kidney transplant recipients with paired protocol biopsies at 3 months and 5 years after transplantation.
Lymphangiogenesis during tubulointerstitial fibrosis to be associated with increased expression of CTGF and VEGF-C (show VEGFC Antibodies) in human obstructed nephropathy as well as in diabetic kidney disease. vitro, CTGF induced VEGF-C (show VEGFC Antibodies) production in HK-2 (show HK2 Antibodies) cells, while CTGF siRNA suppressed transforming growth factor beta1-induced VEGF-C (show VEGFC Antibodies) upregulation.
miR132 may target CTGF in regulating fibrosis in Ang (show ANG Antibodies) IItreated cardiac fibroblasts.
CTGF-mediated temozolomide resistance in glioblastoma operates through TGF-beta1 (show TGFB1 Antibodies)-dependent activation of Smad (show SMAD1 Antibodies)/ERK (show EPHB2 Antibodies) signaling pathways
CCN2 plays a promoting role in hepatocellular carcinoma (HCC (show FAM126A Antibodies))progression through activating LRP6 (show LRP6 Antibodies) in a HSPGs-dependent manner. Heparin in combination with chemotherapy has a synergic effect and could be a treatment choice for HCCs (show HCCS Antibodies) with a high CCN2 expression.
real-time polymerase chain reaction showed higher expression levels of TGF-beta (show TGFB1 Antibodies) and CTGF in desmoid fibromatosis compared with normal skin. The high constitutive expression of beta-catenin (show CTNNB1 Antibodies) downstream effectors; TGF-beta (show TGFB1 Antibodies), CTGF has the potential for enabling targeted therapy
results demonstrated that mechanical stretch and CoCl2-induced HIF-1alpha (show HIF1A Antibodies) together increased the level of MMP-2 (show MMP2 Antibodies) and decreased the levels of VEGF (show VEGFA Antibodies) and CTGF in cultured ACL (show ACLY Antibodies) fibroblasts.
Results confirm the prodevelopmental actions of activin A (show INHBA Antibodies) and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF (show HGF Antibodies) were inhibitory to development.
The results indicate that CTGF suppresses the synthesis of biglycan (show BGN Antibodies) but newly induced that of decorin (show DCN Antibodies) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (show SOX2 Antibodies)-, GFAP (show GFAP Antibodies)-and GFAP (show GFAP Antibodies)/Nestin (show NES Antibodies)-positive cells, activated p44 (show GTF2H2 Antibodies)/42 signaling, and upregulated fibronectin (show FN1 Antibodies). In human glioma cells, it induced GFAP (show GFAP Antibodies) and nestin (show NES Antibodies).
Data show that connective-tissue growth factor regulates signalling through the Wnt (show WNT2 Antibodies) pathway, in accord with its ability to bind to the Wnt (show WNT2 Antibodies) co-receptor LDL receptor (show LDLR Antibodies)-related protein 6 (LRP6 (show LRP6 Antibodies)).
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
A significant increase in TGF-beta1 (show TGFB1 Antibodies) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (show TGFB1 Antibodies) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor
, connective tissue growth factor XCTGF
, Connective tissue growth factor
, connective tissue growth factor-like