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anti-Mouse (Murine) FDFT1 Antibodies:
anti-Rat (Rattus) FDFT1 Antibodies:
anti-Human FDFT1 Antibodies:
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Human Polyclonal FDFT1 Primary Antibody for IHC (p), WB - ABIN389052
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 4 Pubmed References
Cow (Bovine) Polyclonal FDFT1 Primary Antibody for WB - ABIN4271866
Healey, Collier, Griffin, Schuberth, Sandra, Smith, Mahan, Dieuzy-Labaye, Sheldon: Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. in Journal of immunology (Baltimore, Md. : 1950) 2016
Human Polyclonal FDFT1 Primary Antibody for ICC, IF - ABIN4311300
Wu, Hsu, Chen, Yu, Chang, Tai, Liu, Su, Chang, Yu: Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. in Molecular & cellular proteomics : MCP 2010
Human Polyclonal FDFT1 Primary Antibody for IHC (p), ELISA - ABIN4369832
Jiang, McKenzie, Conrad, Shechter: Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase. in The Journal of biological chemistry 1993
Show all 3 Pubmed References
This study demonistrated that fdft1 is regulate the neuronal cholesterol synthesis during neurite outgrowth.
Result provides the first in vivo evidence that SS plays a regulatory role in cholesterol metabolism through modulation of HMG-CoA reductase (show HMGCR Antibodies) activity and cholesterol biosynthesis.
VEGF (show VEGFA Antibodies) expression, APOPTOSIS, AND ANGIOGENESIS in squalene synthase -ablated neural stem cells wERE strongly upregulated
The results indicate that the ennea-peptide CLSPHSMFC, tetra-peptides SMFC, CKTE, and WHQW can effectively inhibit Squalene Synthase activities (IC50 values equal to 64, 76, 87, and 90 muM, respectively)
The minor allele in FDFT1 was associated with advanced fibrosis in the non-steatotic but not in the steatotic subgroup in patients with chronic hepatitis C.
Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-alpha receptor (show TNFRSF1A Antibodies) 1 and nuclear factor-kappaB activation and matrix metallopeptidase (show ECEL1 Antibodies) 1 expression.
Several critical residues that are involved in binding of NADPH (show NQO1 Antibodies) have been identified in the active site of squalene synthase.
HCV infection increases FDFT1 protein level but not FDFT1 mRNA level.
ABHD5 (show ABHD5 Antibodies), PGRMC1 (show PGRMC1 Antibodies) and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features.
FDFT1 and its encoded enzyme, squalene synthase, may play an important role in prostate cancer development and its aggressive phenotypes.
CTSB (show CTSB Antibodies) and FDFT1 are excluded as candidates for keratolytic winter erythema
NASH (show SAMSN1 Antibodies) is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis.
In multivariate models adjusted for age, body mass index, diabetes, waist/hip ratios, and levels of glycated hemoglobin (show HBB Antibodies), the NAFLD (show TSC2 Antibodies) activity score was associated with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1)
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
farnesyl-diphosphate farnesyltransferase 1
, squalene synthase
, Squalene synthetase
, FPP:FPP farnesyltransferase
, squalene synthase-like
, farnesyl-diphosphate farnesyltransferase
, squalene synthetase
, farnesyl diphosphate farnesyltransferase
, presqualene-di-diphosphate synthase