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Full name:: Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Proteins (CTNNA1)

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Synonyms:: 2010010M04Rik, a-cat, AA517462, AI988031, Alpha-Cat, alpha-catenin, alpha-ctn, alphacat, cap102, catna1, CG17947, CT39986, ctnna, ctnna1, Dalpha-cat, DalphaC, Dalphacat, DgriGH19548, dgri_GLEANR_3829, Dmcatp, Dmel\\CG17947, GH19548

list all proteins	Gene Name	GeneID	UniProt
	CTNNA1	1495	P35221
	CTNNA1	12385	P26231
Rat CTNNA1	CTNNA1	307505
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Human Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

The combination of CTNB1, XPO2 (show CSE1L Proteins), and CAPG achieved 95% sensitivity and 96% specificity for the discrimination of these subtypes. We developed two uterine aspirate-based signatures to diagnose Endometrial cancer and classify tumors in the most prevalent histologic subtypes. This will improve diagnosis and assist in the prediction of the optimal surgical treatment
These findings provide mechanistic insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the alpha-catenin-beta-catenin complex in the nucleus.
pseudogene CTNNAP1 is a potential tumor suppressor participating in CRC (show CALR Proteins) pathogenesis by competing with the parent gene CTNNA1 for microRNA-141.
Hypermethylation of the CTNNA1 promoter was associated with unfavorable karyotype, and possessed the higher frequency of coexisting with ASXL1 (show ASXL1 Proteins) and RUNX1 (show RUNX1 Proteins) mutations.
The results of this study demonstrate that causative variants identified in the CTNNA1 and CYP4V2 (show CYP4V2 Proteins) genes are also associated with Leber Congenital Amaurosis.
alpha- and beta-catenins may be important in the early stages of phyllodes tumours development, while E-cadherin (show CDH1 Proteins) may be required for malignant development
This work identified alpha-catenin as another molecule in addition to E- and P-cadherin that were targeted to inactivate homotypic cell-in-cell structures formation in human tumor cells.
Progressive loss of e-cadherin (show CDH1 Proteins)/alpha-catenin expression is associated with an aggressive phenotype (low differentiation, increased metastatic activity/advanced stage) in thyroid carcinomas.
study identifies CTNNA1 gene variants as a cause of macular dystrophy, indicates that CTNNA1 is involved in maintaining RPE (show RPE Proteins) integrity
The results demonstrate a Fas (show FAS Proteins)-mediated apoptotic signaling pathway that is enhanced by the age-dependent loss of alpha(E)-catenin in renal tubule epithelial cells.

Mouse (Murine) Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

alphaE-catenin is essential for inhibiting nuclear YAP (show YAP1 Proteins) localization and cell proliferation. This function of alphaE-catenin is required for formation of the tooth signalling centre, the enamel knot (EK), which maintains dental mesenchymal condensation and epithelial invagination. alphaE-catenin restricts YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) activity to establish a group of non-dividing and specialized cells that constitute a signalling centre.
Catna1 functions as a positive regulator of pancreatic islet cell lineage differentiation by repressing the sonic hedgehog (show SHH Proteins) pathway.
alpha-catenins regulate intercalated disc maturation and actomyosin contractility, which, in turn, control Yap (show YAP1 Proteins) subcellular localization, thus providing an explanation for the loss of proliferative capacity in the newborn mammalian heart.
In this study, the authors revealed how alpha-catenin retains its activated state while avoiding unfolding under tension.
cadherin 2 (CDH2 (show CDH2 Proteins)) and CDH4 (show CDH4 Proteins) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Proteins)) and alpha- and beta-catenins.
alphaT-catenin is a constitutively active actin-binding protein that can physically couple the cadherin.catenin complex to F-actin in the absence of tension.
Two Dtna (show DTNA Proteins) interactors, alpha-catulin (show CTNNAL1 Proteins) (phosphorylation independent) and Grb2 (show GRB2 Proteins) (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.
alphaE-catenin inhibits beta4 integrin-mediated activation of SRC (show SRC Proteins) tyrosine kinase (show TYRO3 Proteins)
E-cadherin (show CDH1 Proteins)/alphaE-catenin chimeras used previously do not mimic alphaE-catenin in the native CCC, and imply that both CCC-bound monomer and cytosolic homodimer alphaE-catenin are required for strong cell-cell adhesion.
Loss of alpha-catenin elicits a cholestatic response and impairs liver regeneration

Fruit Fly (Drosophila melanogaster) Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

alpha-Catenin controls actomyosin dynamics by stabilising and promoting the formation of actomyosin foci, and also stabilises DE-Cadherin (Drosophila E-Cadherin (show CDH1 Proteins), also known as Shotgun) at the cell membrane, suggesting that medioapical actomyosin contractility regulates junction stability.
Increased Rap1 (show TERF2IP Proteins) activity restricts epithelial invagination in an alpha-catenin-dependent manner.
alpha-Cat mutant phenotype can be rescued by the expression of a DE-cadherin::alpha-Catenin fusion protein, which argues against an essential cytosolic, cadherin-independent role of Drosophila alpha-Catenin
alpha-catenin and p120(ctn (show CTNND1 Proteins)) are key players in a mechanism of recruiting Rho1 to its sites of action.

Zebrafish Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

Depletion of alphaE-catenin caused a defect in radial intercalation that was associated with decreased cell-cell adhesion, in a similar manner to E-cadherin (show CDH1 Proteins) depletion. Depletion of alphaE-catenin also caused deep cells to have plasma membrane blebbing.

Xenopus laevis Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

These data suggest that the interactions of beta-catenin with alpha-catenin and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.

Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) Protein Profile

Protein Summary

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Alternative names and synonyms associated with Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1)

catenin alpha 1 (CTNNA1)
catenin (cadherin associated protein), alpha 1 (Ctnna1)
catenin alpha 1 (Ctnna1)
alpha Catenin (alpha-Cat)
alpha Catenin (Dgri\alpha-Cat)
catenin alpha-1 (Tsp_10127)
catenin (cadherin-associated protein), alpha 1 (ctnna1)
catenin alpha 1 S homeolog (ctnna1.S)

2010010M04Rik protein
a-cat protein
AA517462 protein
AI988031 protein
Alpha-Cat protein
alpha-catenin protein
alpha-ctn protein
alphacat protein
cap102 protein
catna1 protein
CG17947 protein
CT39986 protein
ctnna protein
ctnna1 protein
Dalpha-cat protein
DalphaC protein
Dalphacat protein
DgriGH19548 protein
dgri_GLEANR_3829 protein
Dmcatp protein
Dmel\\CG17947 protein
GH19548 protein

Protein level used designations for CTNNA1

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , alpha E-catenin alpha-E-catenin alpha-catenin alphaE-catenin cadherin-associated protein,102kDa catenin alpha-1 renal carcinoma antigen NY-REN-13 a-catenin 102 kDa cadherin-associated protein CAP102 alpha E catenin alpha(E)-catenin cadherin associated protein catenin alpha 1 catenin (cadherin associated protein), alpha 1 catenin, alpha 1 CG17947-PA D-alpha-catenin Dalpha-Catenin Dalpha-cadherin DalphaCatenin alpha catenin alpha-Cat-PA alpha-Catenin alphaCatenin catenin alpha 1 subunit DgriGH19548-PA Dgrialpha-Cat-PA GH19548-PA catenin (cadherin-associated protein), alpha 1, 102kDa catenin alpha-1-like [a]E-catenin catenin alpha 1 S homeolog LOW QUALITY PROTEIN: catenin alpha-1

GENE ID	SPECIES
1495	Homo sapiens
100328952	Oryctolagus cuniculus
12385	Mus musculus
307505	Rattus norvegicus
40517	Drosophila melanogaster
416184	Gallus gallus
450165	Pan troglodytes
526848	Bos taurus
574385	Macaca mulatta
6563215	Drosophila grimshawi
10905794	Trichinella spiralis
100020276	Monodelphis domestica
100091564	Ornithorhynchus anatinus
100407624	Callithrix jacchus
100453792	Pongo abelii
100483944	Ailuropoda melanoleuca
100523778	Sus scrofa
100550456	Meleagris gallopavo
30741	Danio rerio
100072548	Equus caballus
474698	Canis lupus familiaris
399303	Xenopus laevis
100720469	Cavia porcellus

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