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These findings provide mechanistic insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the alpha-catenin-beta-catenin complex in the nucleus.
pseudogene CTNNAP1 is a potential tumor suppressor participating in CRC (show CALR Proteins) pathogenesis by competing with the parent gene CTNNA1 for microRNA-141.
Hypermethylation of the CTNNA1 promoter was associated with unfavorable karyotype, and possessed the higher frequency of coexisting with ASXL1 (show ASXL1 Proteins) and RUNX1 (show RUNX1 Proteins) mutations.
The results of this study demonstrate that causative variants identified in the CTNNA1 and CYP4V2 (show CYP4V2 Proteins) genes are also associated with Leber Congenital Amaurosis.
alpha- and beta-catenins may be important in the early stages of phyllodes tumours development, while E-cadherin (show CDH1 Proteins) may be required for malignant development
This work identified alpha-catenin as another molecule in addition to E- and P-cadherin that were targeted to inactivate homotypic cell-in-cell structures formation in human tumor cells.
Progressive loss of e-cadherin (show CDH1 Proteins)/alpha-catenin expression is associated with an aggressive phenotype (low differentiation, increased metastatic activity/advanced stage) in thyroid carcinomas.
study identifies CTNNA1 gene variants as a cause of macular dystrophy, indicates that CTNNA1 is involved in maintaining RPE (show RPE Proteins) integrity
The results demonstrate a Fas (show FAS Proteins)-mediated apoptotic signaling pathway that is enhanced by the age-dependent loss of alpha(E)-catenin in renal tubule epithelial cells.
Actin-dependent CTNNA1 clustering is a unique molecular mechanism mediating both integrity and reassembly of the cell-cell adhesive interface formed through weak cis (show CISH Proteins)- and trans-intercadherin interactions.
In this study, the authors revealed how alpha-catenin retains its activated state while avoiding unfolding under tension.
cadherin 2 (CDH2 (show CDH2 Proteins)) and CDH4 (show CDH4 Proteins) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Proteins)) and alpha- and beta-catenins.
alphaT-catenin is a constitutively active actin-binding protein that can physically couple the cadherin.catenin complex to F-actin in the absence of tension.
Two Dtna (show DTNA Proteins) interactors, alpha-catulin (show CTNNAL1 Proteins) (phosphorylation independent) and Grb2 (show GRB2 Proteins) (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.
alphaE-catenin inhibits beta4 integrin-mediated activation of SRC (show SRC Proteins) tyrosine kinase (show TYRO3 Proteins)
E-cadherin (show CDH1 Proteins)/alphaE-catenin chimeras used previously do not mimic alphaE-catenin in the native CCC, and imply that both CCC-bound monomer and cytosolic homodimer alphaE-catenin are required for strong cell-cell adhesion.
Loss of alpha-catenin elicits a cholestatic response and impairs liver regeneration
alphaE-catenin binding to filamentous actin favors assembly of unbranched filament bundles that are protected from severing over more dynamic, branched filament arrays.
Fusing VE-cadherin (show CDH5 Proteins) to alpha-catenin presents a mutation, which leads to embryonic lethality, due to a lack of fetal liver hematopoiesis and severe lymphedema but no detectable defects in blood vessel formation and remodeling.
alphaE-catenin recruits vinculin to adherens junctions more effectively than alphaN-catenin, partly because of its higher affinity for actin filaments.
alpha-Catenin controls actomyosin dynamics by stabilising and promoting the formation of actomyosin foci, and also stabilises DE-Cadherin (Drosophila E-Cadherin (show CDH1 Proteins), also known as Shotgun) at the cell membrane, suggesting that medioapical actomyosin contractility regulates junction stability.
Increased Rap1 (show TERF2IP Proteins) activity restricts epithelial invagination in an alpha-catenin-dependent manner.
alpha-Cat mutant phenotype can be rescued by the expression of a DE-cadherin::alpha-Catenin fusion protein, which argues against an essential cytosolic, cadherin-independent role of Drosophila alpha-Catenin
alpha-catenin and p120(ctn (show CTNND1 Proteins)) are key players in a mechanism of recruiting Rho1 to its sites of action.
Depletion of alphaE-catenin caused a defect in radial intercalation that was associated with decreased cell-cell adhesion, in a similar manner to E-cadherin (show CDH1 Proteins) depletion. Depletion of alphaE-catenin also caused deep cells to have plasma membrane blebbing.
These data suggest that the interactions of beta-catenin with alpha-catenin and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
, cadherin-associated protein,102kDa
, catenin alpha-1
, renal carcinoma antigen NY-REN-13
, 102 kDa cadherin-associated protein
, alpha E catenin
, cadherin associated protein
, catenin alpha 1
, catenin (cadherin associated protein), alpha 1
, catenin, alpha 1
, alpha catenin
, catenin alpha 1 subunit
, catenin (cadherin-associated protein), alpha 1, 102kDa
, catenin alpha-1-like
, catenin alpha 1 S homeolog
, LOW QUALITY PROTEIN: catenin alpha-1