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anti-Human FMR1 Antibodies:
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Fruit Fly (Drosophila melanogaster) Monoclonal FMR1 Primary Antibody for ICC, IF - ABIN108598
Wan, Dockendorff, Jongens, Dreyfuss: Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. in Molecular and cellular biology 2000
Show all 7 Pubmed References
Fruit Fly (Drosophila melanogaster) Monoclonal FMR1 Primary Antibody for ICC, IF - ABIN108599
Callan, Clements, Ahrendt, Zarnescu: Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. in Brain research 2012
Show all 7 Pubmed References
Bat Polyclonal FMR1 Primary Antibody for WB - ABIN610747
Anderson, Teutsch, Dong, Wortis: An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1996
Show all 2 Pubmed References
Chlamydomonas reinhardtii (C. reinhardtii) Polyclonal FMR1 Primary Antibody for WB - ABIN1720852
Subramanian, Dubini, Astling, Laurens, Old, Grossman, Posewitz, Seibert: Profiling Chlamydomonas metabolism under dark, anoxic H2-producing conditions using a combined proteomic, transcriptomic, and metabolomic approach. in Journal of proteome research 2014
Human Polyclonal FMR1 Primary Antibody for ELISA, IHC (p) - ABIN451678
Hanson, Blank, Valenzuela, Garner, Madison: The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. in The Journal of physiology 2007
Human Polyclonal FMR1 Primary Antibody for FACS, IHC (p) - ABIN390866
Yuhas, Walichiewicz, Pan, Zhang, Casillas, Hagerman, Tassone: High-risk fragile x screening in Guatemala: use of a new blood spot polymerase chain reaction technique. in Genetic testing and molecular biomarkers 2009
Show all 2 Pubmed References
Human Monoclonal FMR1 Primary Antibody for IF, IHC - ABIN966157
Dobson, Kube, Timmerman, Krushel: Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader. in BMC molecular biology 2008
Human Polyclonal FMR1 Primary Antibody for ELISA, WB - ABIN4312232
Dölen, Osterweil, Rao, Smith, Auerbach, Chattarji, Bear: Correction of fragile X syndrome in mice. in Neuron 2007
Human Polyclonal FMR1 Primary Antibody for ELISA, WB - ABIN560935
Tucker, Richards, Lardelli: Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. in Human molecular genetics 2006
Human Monoclonal FMR1 Primary Antibody for ELISA, WB - ABIN515777
Schutzius, Bleckmann, Kapps-Fouthier, di Giorgio, Gerhartz, Weiss: A quantitative homogeneous assay for fragile X mental retardation 1 protein. in Journal of neurodevelopmental disorders 2013
Stored oocytes lacking FMR1 usually generate embryos with severe neural defects, unlike stored wild-type oocytes, which suggests that translation of multiple large proteins by stored mRNAs is defective in fragile X syndrome and possibly other autism spectrum disorders.
This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28 (show LIN28A Antibodies), known to boost insulin (show INS Antibodies) signaling in stem cells. Via LIN-28 (show LIN28A Antibodies), FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR (show INSR Antibodies)).
DTor and DFMRP immunoreactivities were partially colocalized in several cellular organelles in larval muscles
Fmr1 protein associates with ninaE (show RHO Antibodies) mRNA and represses its translation.
Our data strongly support a gain-of-function pathogenic mechanism of PQBP1 (show PQBP1 Antibodies) c.459_462delAGAG and c.463_464dupAG mutations, and suggest that therapeutic strategies to restore FMRP function may be beneficial for those patients
dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.
results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.
results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 (show TARDBP Antibodies) overexpression
demonstrate that Zfrp8 genetically interacts with Fmr1 and tral (show LSM14A Antibodies) in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways
dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.
CGG repeat length and FMR1 mRNA levels were not associated with performance on any gait domain in Fragile X-associated tremor ataxia syndrome (FXTAS).
The knockdown of FMRP induced miR (show MLXIP Antibodies)-181a expression and contributed to endothelial cell proliferation and angiogenesis. Authors identified CaM as a downstream target of miR (show MLXIP Antibodies)-181a in endothelial cells.
Study found no significant relationship between the longitudinal changes of the CGG repeat in the FMR1 promoter region and premature ovarian failure etiology which can be attributed to the genetic heterogeneity nature of the disease, the possible involvement of the other genomic variations with the ovarian function and the reproductive health.
Agenet domain of FMRP binds FUS (show FUS Antibodies).
Our male patient had a pattern of the FMR1 size mosaic with both premutation (129 CGG) and full mutation (over 200) fragments
AKT (show AKT1 Antibodies) inhibition led to decreased FMRP levels, as expected due to the known FMR1/FMRP negative feedback loop. But rFSH and the mTOR (show FRAP1 Antibodies) inhibition increased them, indicating a decoupling of this FMR1/FMRP negative feedback loop in our model system
The CGG expanded allele of the FMR1 gene might be associated with unexplained multiple miscarriages.
Fragile X-associated disorders encompass several conditions, which are caused by expansion mutations in the fragile X mental retardation 1 (FMR1) gene.
We demonstrate that romidepsin, an inhibitor of class I histone deacetylases, does not activate FMR1 expression in patient cell cultures, whereas vorinostat, an inhibitor of classes I and II histone deacetylases, activates a low level of FMR1 expression in some patient cell lines
the current study shows lower rates of blastocyst development per metaphase II oocyte and 2PN embryos in FMR1 pre-mutation carriers compared to age-matched controls.
We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar (show ADAR Antibodies) genes and Adar2 (show ADARB1 Antibodies) protein increased in fmr1-/- zebrafish
Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.
Findings provide evidence that the complete loss of functional FMR1 protein and change in mTOR (show FRAP1 Antibodies) signaling, results in the premature recruitment and depletion of the primordial follicle pool in a novel Fmr1 KO mouse model.
FMRP inhibits ADAR2 (show ADARB1 Antibodies) activity, absence of FMRP results in defects of RNA editing of neuronal mRNAs in the mouse model of Fragile X Syndrome.
this study establishes that reducing STEP activity with TC-2153 in Fmr1 KO mice reduces AGS (show GLA Antibodies) susceptibility, improves electrophysiologic and synaptic deficits, and normalizes select social and nonsocial anxiety-related behaviors.
Results indicate several sex-specific changes in Fmr1 knockout mice, including male-specific increases in activity levels, and female-specific increases in repetitive behaviors on both the nose-poke assay and motor coordination on the accelerating rotarod task.
The naturally occurring Fragile XFMR1 5' region undergoes inactivation post implantation in a Dicer (show DICER1 Antibodies)/Ago-dependent targeted process which involves local SUV39H (show SUV39H1 Antibodies)-mediated tri (show VANGL2 Antibodies)-methylation of histone H3K9. Fragile X syndrome may come about through inadvertent siRNA-mediated heterochromatinization.
Fmr1 regulates stability of Myf5 (show MYF5 Antibodies) mRNA and skeletal muscle cell renewal.
The results of this study found decreases in either glycinergic or GABAergic inhibition to the medial nucleus of the trapezoid body (MNTB) specific to the tonotopic location within the nucleus in Fmr1 knockout mice.
mGluR5 (show GRM5 Antibodies) was significantly more mobile at synapses in hippocampal Fmr1 KO neurons, causing an increased synaptic surface co-clustering of mGluR5 (show GRM5 Antibodies) and NMDAR (show GRIN1 Antibodies).
The results show that SMNDC1 (show SMNDC1 Antibodies) mRNA 5'-UTR (show UTS2R Antibodies) forms an intramolecular, parallel G quadruplex structure comprised of three G quartet planes, which is bound specifically by FMRP both in vitro and in mouse brain lysates.
Using the Fmr1 null mouse model of fragile X syndrome, brain regions, gene networks, and molecular pathways responsive to a social stimulus have been identified.
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
, Fragile-X mental retardation protein
, drosophila fragile X mental retardation protein
, fragile X
, fragile X mental retardation
, fragile X mental retardation 1
, fragile X mental retardation gene
, fragile X mental retardation protein
, fragile X protein
, fragile X related protein
, fragile X-related
, fragile x related
, fragile X mental retardation protein 1
, fragile X mental retardation protein 1 homolog
, fragile X mental retardation syndrome 1 homolog
, fragile X mental retardation-1 protein
, protein FMR-1
, ragile X mental retardation protein
, fragile X mental retardation 1 protein