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Human Polyclonal MORF4L2 Primary Antibody for ELISA, WB - ABIN268524
Bertram, Bérubé, Hang-Swanson, Ran, Leung, Bryce, Spurgers, Bick, Baldini, Ning, Clark, Parkinson, Barrett, Smith, Pereira-Smith: Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. in Molecular and cellular biology 1999
Suberoylanilide hydroxamic acid enhanced the expression of malignant genes such as MORF4L2 in lung cancer cells remaining after treatment, creating a more drug-resistant state.
can repress or activate the B-myb (show MYBL2 Antibodies) promoter depending on the cell type studied, suggesting that there may be tissue-specific functions of this protein
The transcriptional status of four key genes, thymidylate synthase (TYMS (show TYMS Antibodies)), MORF-related gene X (MRGX), Bcl2 (show BCL2 Antibodies)-antagonist/killer (BAK (show BAK1 Antibodies)), and ATPase (show DNAH8 Antibodies), Cu(2+) transporting beta polypeptide (show MS4A2 Antibodies) (ATP7B (show ATP7B Antibodies)), can accurately predict response to 5-FU.
Data show that MRGX is ubiquitously expressed in all tissues of adult mice and also during embryogenesis, and overlaps with its homolog Mrg15 (show MORF4L1 Antibodies).
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).
mortality factor 4 like 2
, Mortality factor 4-like protein 2
, MORF-related gene X protein
, MSL3-2 protein
, mortality factor 4-like protein 2
, protein MSL3-2
, transcription factor-like protein MRGX
, sid 393
, transcription factor-like protein Mrgx
, liver regeneration-related protein LRRG00119
, MORF-related gene X