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Results suggest that sequence variants in TNC and COL5A1 genes are associated with superficial digital flexor tendinopathy in TB racehorses. In
Both fetal Tn-C variants may represent novel biomarkers that are capable of estimating both pulmonary vascular remodeling and right ventricular load.
high TNC expression correlates with worse prognosis for lung adenocarcinoma and has a role in lung cancer progressoin
Decellularized lung scaffolds treated with FBN-2 (show FBN2 Proteins) and TN-C prior to re-epithelialization supported greater epithelial proliferation and tissue remodeling.
Immunohistochemical analysis shows that the unique association between the CD44 (show CD44 Proteins)+/CD24low/- phenotype and the pronounced production of tenascin C may have a prognostic potential, prospectively indicating the inefficiency of neoadjuvant polychemotherapy (PCT (show UROD Proteins)), in particular that with platinum derivatives, which is used for the standard treatment of triple-negative BC.
Enhanced serum tenascin-C concentrations are closely related to trauma severity and clinical outcomes
Functional studies showed THBS1 (show THBS1 Proteins) and TNC to mediate chemoresistance through the integrin beta1/mTOR (show FRAP1 Proteins) pathway.
Elevated Tenascin-C serum values are associated with non-small cell lung cancer.
Tenascin-C was abundantly secreted by the colon cancer cells with high metastatic potential, and highly expressed in lymph nodes with metastasis.
Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-kappaB in inflammatory breast cancer cells, in particular, to tenascin-C and MPP9.
Metastatic prostate cancer cells cultured on osteo-mimetic surfaces coated with tenascin C exhibited enhanced adhesion and colony formation as mediated by integrin alpha9beta1.
ATF3 promotes macrophage migration and reverses M1polarized macrophages to the M2 phenotype by upregulation of TNC via the Wnt/betacatenin signaling pathway.
housing of TnC-/- mice in enriched environment abolished hyperlocomotion, led to faster habituation to novel environment, strengthened the grasp of fore limbs and partially improved movement coordination, while the swimming ability remained deficient
The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack tenascin-C, the informational content stored by synaptic plasticity is not the same.
Study suggests that tenascin-C (TnC) contributes to the regulation of structural plasticity in the cerebellum and that interactions between TnC and matrix metalloproteinase 9 (show MMP9 Proteins) are likely to be important for these processes to occur.
the exact role of TNC in primary tumor growth
A deficiency of tenascin C interferes with Th1 (show HAND1 Proteins) and Th17 cells, protecting animals from experimental autoimmune encephalomyelitis.
Tenascin-C may be an important mediator in the development of brain edema and blood-brain barrier disruption following subarachnoid hemorrhage, mechanisms for which may involve MAPK (show MAPK1 Proteins)-mediated MMP-9 (show MMP9 Proteins) induction and ZO-1 (show TJP1 Proteins) degradation
TN-C aggravates autoimmune myocarditis by driving the dendritic cell activation and Th17 differentiation via toll-like receptor 4 (show TLR4 Proteins).
TNC supports the stress-induced expression of extracellular matrix that reinforce the aorta and the stress-induced excessive inflammatory response in the aorta.
TNC plays an important role in TMJ wound healing, especially for wounds generated by mechanical stress.
TNC does not appear to contribute directly to outflow resistance in the eye.
TNC could be a potential candidate gene for meat quality traits in pigs.
tenascin binds to fibronectin (show FN1 Proteins) at a cryptic binding site
Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers. Increase of rat soleus muscle loading modifies basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C.
tenascin-C is part of a specialized extracellular matrix in the region of the horizontal myoseptum that influences the growth of motor axons
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
, tenascin C (hexabrachion)
, GP 150-225
, glioma-associated-extracellular matrix antigen
, hexabrachion (tenascin)
, myotendinous antigen
, tenascin-C isoform 14/AD1/16