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Human Polyclonal YBX1 Primary Antibody for IF, WB - ABIN1882002
Osada, Uno, Mineta, Kameoka, Takahashi, Terao: Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta. in Molecular ecology 2010
Show all 5 Pubmed References
Human Polyclonal YBX1 Primary Antibody for ICC, IF - ABIN4366502
Stickeler, Fraser, Honig, Chen, Berget, Cooper: The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. in The EMBO journal 2001
Human Polyclonal YBX1 Primary Antibody for ICC, IF - ABIN4366500
Dey, Robitaille, Remke, Maier, Malhotra, Gregorieff, Wrana, Taylor, Angers, Kenney: YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. in Oncogene 2016
structural basis of the interactions between YB-1 and mRNAs carrying the aforementioned motifs
YB-1 silencing sensitized SH-SY5Y cells to cisplatin and promoted the apoptosis induced by cisplatin due to down-regulation of multidrug resistance (MDR) 1 (show TBC1D9 Antibodies) protein via NF-kappaB (show NFKB1 Antibodies) signaling pathway.
YB-1 promoted lung adenocarcinoma growth and progression in vitro and in vivo through directly binding to the MACC1 promoter and enhancing MACC1/c-Met pathway.
Data indicate that YB-1 translocates to the nucleus coordinately with p53 (show TP53 Antibodies) expression and is involved in gemcitabine resistance in bladder cancer suggesting that nuclear expression of YB-1 is important for resistance to chemotherapy including gemcitabine in TP53 (show TP53 Antibodies)-mutated bladder cancer.
Results show that YBX1 expression is regulated by TP53TG1 which binds to YBX1 promoter and prevents its nuclear localization.
Kindlin-2 (show FERMT2 Antibodies) is up-regulated in glioma cells and acts as an oncogene (show RAB1A Antibodies). It is an independent risk factor for poor prognosis. The Kindlin-2 (show FERMT2 Antibodies)/YB-1/beta-catenin (show CTNNB1 Antibodies) complex promotes EGFR (show EGFR Antibodies) transcription and contributes to glioma progression. Kindlin-2 (show FERMT2 Antibodies) is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 (show FERMT2 Antibodies) may be a novel strategy for glioma treatment.
Results showed that YB-1 promoted hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cell proliferation, migration and colony formation. Also, YB-1 was found to increased drug resistance in HCC (show FAM126A Antibodies). These findings suggested that YB-1 was a key factor in HCC (show FAM126A Antibodies) tumorigenesis and maintained the HCC (show FAM126A Antibodies) initiating cell population.
Furthermore, use of both indirubin 3'-oxime and actinomycin D in combination increased the anticancer effect on HepG2 cells. Indirubin 3'-oxime is a novel and efficient inhibitor of anticancer agent-induced YB-1 nuclear translocation.
It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C (show CORO1C Antibodies). The association between YB-1 and coronin-1C (show CORO1C Antibodies) offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated.
Inhibition of YBX1 suppressed lung cancer growth partly via the CDC25a pathway and high expression of YBX1/CDC25a predicts poor prognosis in human lung adenocarcinoma.
The amounts of YB-1 and YB-1 mRNA in rabbit organs and several cell lines.
results prove direct inhibitory action of YB-1 on its mRNA translation, while the positive effect of PABP (show PABPC1 Antibodies) is realized through displacing YB-1 from the regulatory element
YB-1 orchestrates onset and resolution of renal inflammation via IL-10 (show IL10 Antibodies) gene regulation.
Monocytic YB-1 has prominent and distinct roles for cellular feed-forward crosstalk and resolution of inflammatory processes by its ability to regulate cell differentiation and cytokine/chemokine (show CCL1 Antibodies) synthesis.
YB-1 is induced by Shh (show SHH Antibodies) in CGNPs
this study shows that innate immunity activation by muramyl peptides is mediated via an interaction between YB1 and NOD2 (show NOD2 Antibodies)
In conclusion, TGF-beta (show TGFB1 Antibodies) signaling pathway may influence liver fibrosis by incorporating with YB-1, indicating that YB-1 could be a potential target for therapies against liver fibrosis.
Reduction in the expression of YBX1 and ILF3 controls the expression of pluripotency-related genes in ESCs (show NR2E3 Antibodies), suggesting their roles in further regulation of the pluripotent state of ESCs (show NR2E3 Antibodies).
In the initial stage of myocyte differentiation, transcription of the YB-1 gene was regulated by E2F1 (show E2F1 Antibodies) and Sp1 (show SP1 Antibodies), and was then gradually replaced under the control of both MyoD (show MYOD1 Antibodies) and myogenin (show MYOG Antibodies).
YB-1 is a novel intracellular target of activated protein C (show PROC Antibodies) in renal ischemia-reperfusion injury
miR (show MLXIP Antibodies)-382 inhibits osteosarcoma metastasis and relapse by targeting YB-1 protein.
YB-1 was revealed in a population of Cajal bodies in 2-cell mouse embryos but not in other cells studied.
transcription factor; acts as a regulator of protein tyrosine phosphatase PTP1B expression
B box-binding protein
, CCAAT-binding transcription factor I subunit A
, DNA-binding protein B
, Y-box transcription factor
, Y-box-binding protein 1
, enhancer factor I subunit A
, major histocompatibility complex, class II, Y box-binding protein I
, nuclease sensitive element binding protein 1
, nuclease-sensitive element-binding protein 1
, CCAAT-binding transcription factor 1 subunit A
, DNA binding protein B
, Y box transcription factor
, enhancer factor 1 alpha
, enhancer factor 1 subunit A
, FRG Y
, frg y1
, frog Y-box proteins
, Y-box binding protein 1