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Polyclonal AVPR1B Primary Antibody for ELISA, WB - ABIN539741
Dempster, Burcescu, Wigg, Kiss, Baji, Gadoros, Tamás, Kennedy, Vetr, Kovacs, Barr: Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. in Archives of general psychiatry 2007
Show all 2 Pubmed References
Zebrafish avtr1a1 and avtr1a2 receptors are expressed primarily in the CNS in similar but generally non-overlapping patterns.
AVP 1b receptor contributes to the amygdaloid modulation of anxiety
Patients were different from those previously studied. We measured the expression of the pituitary-specific hormone genes and type 1 corticotrophin-releasing hormone and arginine vasopressin 1b receptors, by quantitative real-time polymerase chain reaction using TaqMan probes.
Polymorphisms of CRHR1 and AVPR1b may modify susceptibility to mood disorders.
The results suggest that the AVPR1B gene rs28373064 is linked to emotional empathy and prosociality.
AA genotype of rs28418396 single-nucleotide polymorphism near the arginine vasopressin receptor 1b gene is associated with serious adverse events in patients with septic shock treated with vasopressin and norepinephrine.
Genetic variance of arginine vasopressin receptor 1B(AVPR1B) contributes to overweight and data indicate a link between AVPR1B variance and diabetes mellitus development
The association of AVPR1B G*A-haplotype (rs28632197 and rs33911258, respectively) and decreased Self-transcendence (TCI-125) was demonstrated in the total sample and in Udmurts.
Participants carrying both GG/GA variant of AVPR1b rs28373064 and AA variant of clock rs6832769 showed highest scores on the Emotional prosocial tendency measure. the clock gene and OXT/AVP systems are intertwined and contribute to human prosociality.
The associations of the AVP 1B receptor may be specific to reactive, emotional rather than proactive or callous types of aggression.
association between polymorphisms of AVPR1b gene and psychotic dimension.possible involvement of the AVPR1b gene in the etiology of psychotic features in the course of affective disorders
AVPR1B genetic variation has a role in suicide attempt etiology characterized by elevated depression levels.
The results of thi study showed that no association was found for alleles, genotypes, or haplotype analysis for AVPR1b genes and melancholic depression.
This is the first report of a genetic association between vasopressin receptor 1B and child aggression.
polymorphism rs28536160 genotype TT of the AVPR1b gene may increase susceptibility for obtaining psychotic features in the course of bipolar disorder I.
the presence of V1b receptors also found in human Langerhans islets could suggest hormonal control of AVP in human pancreas.
Data supports a protective effect of this major haplotype for recurrent major depression.
determination of a C-terminal motif required for export to plasma membrane
V1bR and CRHR1 can form constitutive homo- and heterodimers.
study found evidence to implicate the AVPR1B gene in the etiology of mood disorders, particularly in females
polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder
No difference between wild-type (WT) and v1a and v1b double knockout (dKO) mice was found in olfactory preferences for estrous female odor to male odor. Over all four mating tests, the number of mounts and pursuits after receptive females was significantly greater in dKO mice than in WT mice. In the elevated plus maze and the open field test, dKO mice showed lower anxiety-like behavior than WT mice.
These findings indicate that inhibition of mu-opioid-receptor-associated V1bR provides an approach for enhancing morphine analgesia without increasing analgesic tolerance
Data indicate the upregulation of vasopressin receptor 1 (V1R) expression on hepatocytes upon liver ischemia-reperfusion injury (IRI).
Data identify specific brain areas that may be a part of a neural circuit that includes Avpr1b-expressing cells in the CA2 region of the hippocampus. It is thought that this circuit, when working properly, plays a role in how an animal evaluates its social context.
Data show that cryptochrome Cry1 and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP) receptor signaling is required to impose circuit-level circadian function.
The data of this study indicate that the hippocampal CA2 is important for attacking in response to a male intruder and that the Avpr1b, likely through its role in regulating CA2 synaptic plasticity, is a necessary mediator
this study found that circadian rhythms of behavior (locomotor activity), clock gene expression, and body temperature immediately reentrained to phase-shifted light-dark cycles in mice lacking vasopressin receptors V1a and V1b (V1a(-/-)V1b(-/-)).
vasopressin V1b receptor is involved in the mediation of anxious behavior of animals but is not involved in the mechanism underlying the influence of negative psychoemotional state on Lewis lung carcinoma metastasis
distribution and functional studies of the Avpr1b have established its major role in the pituitary where it plays a pivotal part in the regulation of the HPA response to stress, and in particular to acute stress[review]
These findings suggest that while Avpr1b -/- mice may be able to form dominance hierarchies they appear to employ alternate strategies.
Overexpression of the V3 vasopressin receptor in transgenic mice corticotropes leads to increased basal corticosterone.
mice without the V1bR exhibit markedly reduced aggression and modestly impaired social recognition.
the V1b receptor plays a crucial role in regulating hypothalamic-pituitary-adrenal axis activity
We found especially prominent Avpr1b expression within the CA2 pyramidal neurons of the hippocampus, with much lower expression in the hypothalamic paraventricular nucleus and amygdala.
Avpr1b is required for the normal pituitary and adrenal response to some acute stressful stimuli and is necessary only for a normal ACTH response during chronic stress.
Avpr1b plays an important role in the central processing that couples the detection and perception of social cues
stress responsive AVP/V1b receptor systems may be critical components of the neural circuitry underlying the aversive emotional consequences of drug withdrawal.
Thus, the findings suggest that the V(1b) receptor may be, at least in part, involved in body water balance and body temperature regulation.
Fasting plasma glucose, insulin and glucagon levels were lower in V1bR(-/-) mice. Insulin-stimulated phosphorylation of Akt was increased in their adipocytes.
V2r1b vomeronasal sensory neurons responded to prolonged depolarization with persistent, but adapting discharge that could be relevant in sensory adaptation
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.
pituitary vasotocin receptor
, vasopressin V1b receptor
, arginine vasopressin receptor 1B
, vasopressin V1b receptor-like
, AVPR V1b
, AVPR V3
, antidiuretic hormone receptor 1B
, arginine vasopressin receptor 3
, pituitary vasopressin receptor 3
, vasopressin V3 receptor
, V3/V1b pituitary vasopressin receptor
, antidiuretic hormone receptor 1b
, arginine vasopressin type 1b receptor
, AVP receptor V3