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anti-Human TACR1 Antibodies:
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Human Polyclonal TACR1 Primary Antibody for ICC, FACS - ABIN152468
Lai, Ho, Kilpatrick, Wang, Tuluc, Korchak, Douglas: Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 38 Pubmed References
Guinea Pig Polyclonal TACR1 Primary Antibody for ICC, IHC (fro) - ABIN152451
Anderson, Seybold: Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception. in Neuroscience letters 2000
Show all 31 Pubmed References
Human Polyclonal TACR1 Primary Antibody for ELISA, WB - ABIN563081
Chernova, Lai, Li, Schwartz, Tuluc, Korchak, Douglas, Kilpatrick: Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). in Journal of leukocyte biology 2008
Human Polyclonal TACR1 Primary Antibody for ICC, IF - ABIN261566
Cavanaugh, Lee, Lo, Shields, Zylka, Basbaum, Anderson: Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. in Proceedings of the National Academy of Sciences of the United States of America 2009
Cow (Bovine) Polyclonal TACR1 Primary Antibody for IHC (p) - ABIN4339804
Chui, Di Girolamo, Coroneo, Wakefield: The role of substance P in the pathogenesis of pterygia. in Investigative ophthalmology & visual science 2007
Human Polyclonal TACR1 Primary Antibody for FACS, ICC - ABIN4235052
Altawil, Lyström, El-Nour: Kinetics of neuronal contribution during the development of a contact allergic reaction. in Archives of dermatological research 2012
Human Monoclonal TACR1 Primary Antibody for FACS - ABIN4898761
Taracanova, Alevizos, Karagkouni, Weng, Norwitz, Conti, Leeman, Theoharides: SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. in Proceedings of the National Academy of Sciences of the United States of America 2017
Study revealed extensive distribution of SP and NK1R in nuclei intimately related to cardiorespiratory function and autonomic control, with significant co-distribution and co-localization with 5-HT (show DDC Antibodies) in the medullary network in the normal human infant during development. A trend for NK1R binding to decrease with age was observed with significantly higher binding in premature and male infants.
These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells.
These results reveal a critical role for endosomal signaling of the NK1R in the complex pathophysiology of pain.
The percentages of SP+ and NK1R+ expression populations of monocytes, helper T cells, natural killer T cells and basophils in peripheral blood of eczema patients were markedly elevated.
elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.
Expression of NK1R increases in the eosinophils of chronic spontaneous urticaria (CSU) patients. Blockers of NK1R might be used for CSU treatment.
NK-1R may positively regulate melanogenesis through Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
This study revealed for the first time an increase of Mast Cells -nerve association and NK1R expression on Mast Cells during Allergic Rhinitis as well as nerve fibres containing receptors for mass cells.
Kinase activation led to increased MMP-2 (show MMP2 Antibodies) and MT1-MMP (show MMP14 Antibodies) expression and melanoma cell migration induced by hHK-1 (show HOOK1 Antibodies). Thus, hHK-1 (show HOOK1 Antibodies) and the NK1 receptor are critical to melanoma cell migration and each may be a promising chemotherapeutic target
Within a small cohort of patients who presented for treatment,a novel gene was identified that appears to contribute to anorexia nervosa pathophysiology, TACR1.
BoNT/A antinociceptive activity is dependent on integrity of SP/NKA and NK1R.
results indicate the contribution of NK1R signaling in maintaining the homeostasis of the ocular surface under steady-state condition, and that the lack of functional NK1R increases the susceptibility of eyes to develop severe herpes stromal keratitis upon ocular HSV-1 infection
the NK1R-CreER mouse line is a valuable new tool for conditional gene manipulation enabling the visualization and manipulation of cells that express NK1R.
NK1R-/- mice did not exhibit excessive false alarms, compared with wildtypes (response disinhibition) but, as in the 5-Choice ContinuousPerformance Test, they exhibited more perseverative responses throughout the test
NK1R-expressing dorsal horn neurons play a major role in the expression of symptoms of chronic itch.
The results of this study indicated that certain behaviours, disrupted in ADHD, are influenced by an interaction between the BRAS and NK1R, and suggest that ACE (show ACE Antibodies) inhibitors could provide a novel treatment for this disorder.
Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P (show TAC1 Antibodies) to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS (show NOS1 Antibodies) and the NK-1R
the hyperactivity, perseveration and, possibly, inattentiveness of NK1R-/- mice is a direct consequence of a lack of functional NK1R
Substance P (show TAC1 Antibodies) partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 (show CYBB Antibodies) axis-mediated pathway.
Implanting vascular bundles into the tissue engineered bone can significantly improve the expression levels of NK1R and VIPR1 (show VIPR1 Antibodies).
Activation of neurokinin-1 (show TAC1 Antibodies) receptors in primary sensory neurons plays a role in the generation of overactive bladder.
Substance P (show TAC1 Antibodies) and SP-R mRNA expressions were reduced after IMETIT treatment of allergic rhinitis.
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
, substance-P receptor
, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
, Nk1 receptor
, neurokinin receptor 1
, substance P receptor
, neurokinin 1 receptor
, substance p receptor
, neurokinin receptor subtype NK1
, tachikinin receptor 1
, tachykinin receptor 1
, neurokinin-1 receptor