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anti-Human TACR1 Antibodies:
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Human Polyclonal TACR1 Primary Antibody for ICC, FACS - ABIN152468
Lai, Ho, Kilpatrick, Wang, Tuluc, Korchak, Douglas: Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 39 Pubmed References
Guinea Pig Polyclonal TACR1 Primary Antibody for ICC, IHC (fro) - ABIN152451
Anderson, Seybold: Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception. in Neuroscience letters 2000
Show all 32 Pubmed References
Polyclonal TACR1 Primary Antibody for IHC (fro), WB - ABIN540271
Hazlett, McClellan, Barrett, Liu, Zhang, Lighvani: Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. in Investigative ophthalmology & visual science 2007
Show all 4 Pubmed References
Polyclonal TACR1 Primary Antibody for IHC (fro), WB - ABIN540270
Kc, Haxhiu, Tolentino-Silva, Wu, Trouth, Mack: Paraventricular vasopressin-containing neurons project to brain stem and spinal cord respiratory-related sites. in Respiratory physiology & neurobiology 2002
Show all 3 Pubmed References
Human Polyclonal TACR1 Primary Antibody for ELISA, WB - ABIN563081
Chernova, Lai, Li, Schwartz, Tuluc, Korchak, Douglas, Kilpatrick: Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). in Journal of leukocyte biology 2008
Human Polyclonal TACR1 Primary Antibody for ICC, IF - ABIN261566
Cavanaugh, Lee, Lo, Shields, Zylka, Basbaum, Anderson: Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. in Proceedings of the National Academy of Sciences of the United States of America 2009
Human Polyclonal TACR1 Primary Antibody for FACS, ICC - ABIN4235052
Altawil, Lyström, El-Nour: Kinetics of neuronal contribution during the development of a contact allergic reaction. in Archives of dermatological research 2012
Cow (Bovine) Polyclonal TACR1 Primary Antibody for IHC (p) - ABIN4339804
Chui, Di Girolamo, Coroneo, Wakefield: The role of substance P in the pathogenesis of pterygia. in Investigative ophthalmology & visual science 2007
structure of hNK1R is a valuable tool in the further development of tachykinin receptor modulators for multiple clinical applications
Study report high-resolution crystal structures of the human NK1 receptor (NK1R) bound to two small-molecule antagonist therapeutics. The structures reveal the detailed interactions between antagonists and NK1R, which induce a distinct receptor conformation resulting in an interhelical hydrogen-bond network that cross-links the extracellular ends of helices V and VI.
MiR-34b/c-5p and NK1R contribute to breast cancer cell proliferation and apoptosis and are potential targets for breast cancer therapeutics.
the results of our systemic study increases our knowledge of the roles of NK1R and 5-HT1AR in melanogenesis and provides possible, novel therapeutic strategies for treatment of skin hypo/hyperpigmentation.
MiR-22 downregulated the expression of NK1R-Truncated and ER-alpha to delay and weaken phosphorylation of ERK1/2 to inhibit proliferation and metastasis of breast cancer cells.
The neuropeptide, substance P (SP), is the physiological ligand of the neurokinin-1 (NK-1) receptor that is consistently overexpressed in glioblastoma cells. The aim of this work was to study physico-chemical and biological properties of different SP analogues labeled with technetium-99m and lutetium-177 radionuclides.
NK-1RA is recommended to use in carboplatin-based chemotherapy, not oxaliplatin-based chemotherapy
Study revealed extensive distribution of SP and NK1R in nuclei intimately related to cardiorespiratory function and autonomic control, with significant co-distribution and co-localization with 5-HT in the medullary network in the normal human infant during development. A trend for NK1R binding to decrease with age was observed with significantly higher binding in premature and male infants.
These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the adipose stem cells.
These results reveal a critical role for endosomal signaling of the NK1R in the complex pathophysiology of pain.
The percentages of SP+ and NK1R+ expression populations of monocytes, helper T cells, natural killer T cells and basophils in peripheral blood of eczema patients were markedly elevated.
elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.
Expression of NK1R increases in the eosinophils of chronic spontaneous urticaria (CSU) patients. Blockers of NK1R might be used for CSU treatment.
NK-1R may positively regulate melanogenesis through Wnt/beta-catenin signaling pathway.
This study revealed for the first time an increase of Mast Cells -nerve association and NK1R expression on Mast Cells during Allergic Rhinitis as well as nerve fibres containing receptors for mass cells.
Kinase activation led to increased MMP-2 and MT1-MMP expression and melanoma cell migration induced by hHK-1. Thus, hHK-1 and the NK1 receptor are critical to melanoma cell migration and each may be a promising chemotherapeutic target
Within a small cohort of patients who presented for treatment,a novel gene was identified that appears to contribute to anorexia nervosa pathophysiology, TACR1.
NK1 receptor expression is increased in colonic tissues from experimental colitis models and in the colon of Irritable Bowel Disease patients.
High Truncated Neurokinin-1 Receptor expression is associated with Neuroblastoma.
Abnormalities in substance P neurokinin-1 receptor binding in key brainstem nuclei is associated with sudden infant death syndrome.
Our results suggest that the NK1 receptor contributes to the early phase of LPS-induced fever by enhancing COX-2 protein expression in the periphery.
BoNT/A antinociceptive activity is dependent on integrity of SP/NKA and NK1R.
results indicate the contribution of NK1R signaling in maintaining the homeostasis of the ocular surface under steady-state condition, and that the lack of functional NK1R increases the susceptibility of eyes to develop severe herpes stromal keratitis upon ocular HSV-1 infection
the NK1R-CreER mouse line is a valuable new tool for conditional gene manipulation enabling the visualization and manipulation of cells that express NK1R.
NK1R-/- mice did not exhibit excessive false alarms, compared with wildtypes (response disinhibition) but, as in the 5-Choice ContinuousPerformance Test, they exhibited more perseverative responses throughout the test
NK1R-expressing dorsal horn neurons play a major role in the expression of symptoms of chronic itch.
The results of this study indicated that certain behaviours, disrupted in ADHD, are influenced by an interaction between the BRAS and NK1R, and suggest that ACE inhibitors could provide a novel treatment for this disorder.
Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS and the NK-1R
the hyperactivity, perseveration and, possibly, inattentiveness of NK1R-/- mice is a direct consequence of a lack of functional NK1R
Substance P partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 axis-mediated pathway.
Arsenic may initiate endothelial dysfunction, resulting in vascular leakage in response to vasoactive agents.
NK1-R expression in the trachea, bronchus, and lung tissue increased in MP-infected BALB/c mice, which may explain why wheezing occurs after MP infection.
The behavioural response of mice lacking NK1r to guanfacine resembles its clinical profile in treatment of ADHD
Together, our findings revealed a critical role of microglial NOX2 in mediating the neuroinflammatory and dopaminergic neurodegenerative effects of SP, which may provide new insights into the pathogenesis of PD.
Both PACAP and SP/NKA, but not NK1 receptors participate in normal motor coordination.
These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in collagen antibody-induced arthritis A.
obese-asthma phenotype in mice is accompanied by increased expression of NK1-R on adipose tissues and lung epithelium, reflecting that SP released during inflammation may act directly on these tissues. Blocking NK1-R affects lymphangiogenesis
bone marrow taken from NK-1R deficient mice (Tacr1(-/-)) showed lineage specific B and T cell engraftment deficits compared to wild-type competitor bone marrow cells
Data indicate that NK1R-dendritic cells (DCs) promote cellular immunity that requires IL-12p70.
Implanting vascular bundles into the tissue engineered bone can significantly improve the expression levels of NK1R and VIPR1.
Activation of neurokinin-1 receptors in primary sensory neurons plays a role in the generation of overactive bladder.
Substance P and SP-R mRNA expressions were reduced after IMETIT treatment of allergic rhinitis.
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
, substance-P receptor
, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
, Nk1 receptor
, neurokinin receptor 1
, substance P receptor
, neurokinin 1 receptor
, substance p receptor
, neurokinin receptor subtype NK1
, tachikinin receptor 1
, tachykinin receptor 1
, neurokinin-1 receptor