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High levels of CSTA expression in Esophageal Squamous Cell Carcinoma were correlated with tumor progression and advanced cancer stage, including lymph node metastasis.
UV phototoxicity-induced pre-elafin (show PI3 Proteins) inside keratinocytes prior to cornified envelope formation could be involved in UV-induced keratinocyte apoptosis via cystatin-A downregulation resulting in pro-caspase-3 (show CASP3 Proteins) activation.
Identify myoepithelial cell stefin A as a suppressor of early tumor invasion and a candidate marker to distinguish patients who are at low risk of developing invasive breast cancer.
Expression of CSTA was detected in some tumor tissues and many tumor-infiltrating immune cells. Cathepsin B (show CTSB Proteins) expression was also observed in most tumor tissues and tumor-infiltrating immune cells
The results suggest that C12orf39, CSTA, and CALCB (show CALCB Proteins) are novel ATF4 (show ATF4 Proteins) target genes, and that C12orf39 promoter activity is activated by ATF4 (show ATF4 Proteins) through amino acid response element.
CSTA/TYROBP (show TYROBP Proteins) gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis .
High expression of stefin A may be an important factor contributing to the development and metastasis of Hepatocellular Carcinoma.
Both MIP-3alpha (show CCL20 Proteins) and cystatin A overexpressions in NPC (show NPC1 Proteins) tumor tissues were strong independent factors of poor prognosis in NPC (show NPC1 Proteins) patients.
a novel pathway of CSTA regulation involving Dsg2 (show DSG2 Proteins)
We identified a homozygous nonsense mutation (p.Lys22X) in the CSTA gene in acral peeling skin syndrome.
analysis of a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
, cystatin A (stefin A)
, stefin A