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anti-Human PNMT Antibodies:
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Human Polyclonal PNMT Primary Antibody for IF (p), IHC (p) - ABIN751033
Kawahata, Yamakuni et al.: Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N-methyltransferase mRNA expression to enhance catecholamine synthesis and its ... in Toxicology 2018
Nicotinic stimuli appear to regulate expression of the epinephrine-synthesizing gene PNMT through a previously uncharacterized regulatory element.
PNMT gene is located within human chromosome 17q12 amplicon, including PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes. PPP1R1B ~ ERBB2 ~ GRB7 locus is amplified in human gastric cancer and breast cancer.
PNMT underexpression is associated with malignant pheochromocytoma and paraganglioma.
initial velocity studies on human PNMT in the absence and presence of product and dead end inhibitors.
The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese.
PNMT G-390A polymorphism is possibly associated with essential hypertension risk in male Chinese Han population.
In Caucasians, phenylethanolamine N-methyltransferase single nucleotide polymorphisms are associated with the development of acute kidney injury, disease severity, and in-hospital mortality.
PNMT variants in cis may interact with nuclear factors in trans to govern adrenergic activity.
Human PNMT has been crystallized in complex with an inhibitor and the cofactor product S-adenosyl-L-homocysteine and diffraction data measured from a cryocooled crystal extend to a resolution of 2.3 A.
pharmacologic and biochemical evidence of beta-carboline 2N-methyltransferase activity
Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis.
homozygosity/heterozygosity of the phenylethanolamine N-methyltransferase gene polymorphism was highly predictive of significant weight loss with sibutramine during the first 3 months of obesity treatment
genetic variants of PNMT may play a role in the development of essential hypertension.
Presence of local PNMT transcription in human heart after transplantation.
disulfide-linked dimers are as active as the monomeric enzyme indicating that the crystal structure of the protein is a valid target for inhibitor design.
Results suggest that PNMT catalyzes transfer of methyl to ligand amines only when "anchor" interactions, such as those identified for the beta-hydroxyls of p-octopamine and cis-AT, are present.
the differences in PNMT expression between normotensives and hypertensives are not determined by the polymorphisms in this gene, but rather by the interplay of gene expression regulators, which may vary among individuals
We examined the correlation between reward dependence (RD) trait, and 5 polymorphisms in genes of norepinephrine pathways. We found that rs3764351 in PNMT was significantly associated with reward dependence trait.
Haplotypes of the phenylethanolamine N-methyltransferase (PNMT), catechol-O-methyltransferase (COMT) have functionally important effects on alcohol-induced cardiovascular symptoms by affecting blood catecholamine levels.
The crystal structures illustrate the adaptability of the PNMT substrate binding site in accepting multi-fused ring systems, such as substituted norbornene, as well as noradrenochrome, the oxidation product of noradrenaline.
the reaction takes place via an SN2 mechanism with methyl transfer being rate-limiting
Data suggest that Pnmt plays role in fear response and startle reactivity; compared with wild-type mice, Pnmt-knockout mice exhibit reduced contextual fear but normal cued fear.
Although temperature was normal in Pnmt(-/-) mice, the brown fat response to cold was abnormal with no increase in Ucp-1 or Pgc-1alpha mRNA levels (but with an exaggerated cold-induced lipid loss from the tissue).
surprisingly high levels of the epinephrine synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) were detected in the thymus of young mice.
A truncated mouse phenylethanolamine N-methyltransferase splice variant has dominant-negative activity
PNMT expression is regulated late in mouse gestation by AP2-alpha and glucocorticoids
Glucocorticoid receptors form multimers of Pmnt independent of the DNA binding domain.
clear, significant increase in aggression arising from PNMT overexpression
Regulation of the PNMT gene expression in various compartments of heart includes both corticosterone-dependent and independent mechanisms.
Transcriptional suppression by cAMP as a mechanism for regulating PNMT expression in both normal and neoplastic mouse chromaffin cells.
Epinephrine is required for normal blood pressure and cardiac filling responses to stress but is not required for tachycardia during stress or normal cardiovascular function at rest in the knockout mouse.
Neuronal nitric oxide synthase gene inactivation reduces the expression of vasopressin in the hypothalamic paraventricular nucleus and of PNMT in the adrenal gland of the mouse.
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene.
, noradrenaline N-methyltransferase
, phenylethanolamine N-methylase