PNMT antibody (N-Term)

Catalog No. ABIN954226

This Mouse Monoclonal antibody specifically detects PNMT in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for PNMT antibody (N-Term) (ABIN954226)

Target: PNMT (Phenylethanolamine N-Methyltransferase (PNMT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PNMT antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT1C11

Product Details anti-PNMT Antibody

Binding Specificity: AA 1-282, N-Term

Specificity: The antibody recognizes human PNMT. Other species not tested.

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human PNMT (1-282aa) purified from E. coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PNMT

Target: PNMT (Phenylethanolamine N-Methyltransferase (PNMT))

Alternative Name: PNMT / PENT

Background: Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine and plays an important role in regulating cardiovascular function. Expression of PNMT is regulated by hormonal and neural stimuli because its promoter contains sequences responding to cholinergic and depolarization stimuli. PNMT is the final enzyme in the catecholamine pathway, catalyzing the conversion of norepinephrine to epinephrine using as the cosubstrate and methyl donor, S-adenosylmethionine.Synonyms: Noradrenaline N-methyltransferase, PNMTase, Phenylethanolamine N-methyltransferase

Gene ID: 5409

NCBI Accession: NP_002677

UniProt: P11086

Pathways: Response to Water Deprivation