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this study shows an eventually involvement of CREM gene in the development of T1D pathology in Tunisian families. These facts are consistent with a major role for transcription factor genes involved in the immune pathways in the control of autoimmunity.
Data indicate a role for inducible cyclic AMP early repressor (ICER) in G1 checkpoint regulation in hematopoietic stem cells (HSCs).
Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1 (show EWSR1 Proteins)-AFT1/CREB1 (show CREB1 Proteins)/CREM fusions.
Study provides evidence that increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates CREMA in systemic lupus erythematosus.
These findings indicated that the polymorphisms of CREM gene were associated with nonobstructive azoospermia in the Chinese population and low CREM expression might be involved in the pathogenesis of spermatogenesis maturation arrest.
In Alzheimer's brain, we found an increased cellular expression of CREM in dentate gyrus neurons as compared to normal aging brains.
Data suggest ICER/CREM plays seminal role in down-regulation of expression/secretion of insulin (show INS Proteins) by pancreatic beta-cell as an adaptive response to factors that promote diabetes; inappropriate induction of ICER leads to beta-cell dysfunction. [REVIEW]
CaMK4 (show CAMK4 Proteins)-dependent activation of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and CREM-alpha underlies autoimmunity-associated Th17 imbalance.
CREMalpha orchestrates epigenetic remodeling of the CD8A (show CD8A Proteins),B through the recruitment of DNA methyltransferase (show DNMT1 Proteins) (DNMT (show DNMT1 Proteins)) 3a and histone methyltransferase G9a (show EHMT2 Proteins).
Data suggest that cyclic AMP (show APRT Proteins) response element modulator-1 (CREM-1) might play an important role in the regulation of tumor metastasis and invasion and serve as a tumor suppressor in esophageal squamous cell carcinoma (ESCC).
results are consistent with the suggestions that cAMP responsive element modulator variants are involved in spermiogenesis in the testes of Japanese Black bulls
Deficiency in ICER elevated binding of NF-kappaB (show NFKB1 Proteins) to promoters of pro-inflammatory genes and their subsequent gene expression. Mice deficient in ICER were hypersensitive to LPS (show TLR4 Proteins)-induced endotoxic shock and showed propagated inflammation.
The transcription factor CREM was found to be important in the regulation of cardiotoxicity-associated genes.
Our results demonstrate that overexpression of CREMalpha in T cells changes the inflammatory milieu, attenuating initiation and progression of CLD (show LMF1 Proteins).
the role of ICER in ovarian function, was investigated.
Phosphorylated Tssk4 (show TSSK4 Proteins) might participate in testis genes expressions by phosphorylating Crem at Ser (show SIGLEC1 Proteins)-117.
the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression.
Crem(-/-) mice exhibited increased proliferation of primary aortic VSMCs along with upregulation of PDGF (show PDGFA Proteins) signaling.
These data identify ICER as a redundant mediator of Treg cells and cAMP action on Teff cells and suggest that Epac (show RAPGEF3 Proteins) may function as an alternative effector to promote cAMP-dependent Teff cell suppression.
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
cAMP responsive element modulator
, cAMP response element modulator tau
, ICER protein
, cAMP-responsive element modulator
, CREM 2alpha-b protein
, CREM 2beta-a protein
, cAMP response element modulator
, inducible cAMP early repressor ICER
, cAMP responsive element moderator
, cAMP-responsive element moderator
, CRE modulator
, inducible cyclic AMP early repressor