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anti-Human EZH2 Antibodies:
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Human Polyclonal EZH2 Primary Antibody for ChIPSeq, ChIP - ABIN2668958
Knutson, Kawano, Minoshima, Warholic, Huang, Xiao, Kadowaki, Uesugi, Kuznetsov, Kumar, Wigle, Klaus, Allain, Raimondi, Waters, Smith, Porter-Scott, Chesworth, Moyer, Copeland, Richon, Uenaka, Pollock et al.: Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. ... in Molecular cancer therapeutics 2014
Show all 9 Pubmed References
Human Monoclonal EZH2 Primary Antibody for ChIP - ABIN2668955
Bengani, Mendiratta, Maini, Vasanthi, Sultana, Ghasemi, Ahluwalia, Ramachandran, Mishra, Brahmachari: Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome. in PLoS ONE 2013
Show all 8 Pubmed References
Human Polyclonal EZH2 Primary Antibody for WB - ABIN2668957
Izzo, Mercogliano, Venturutti, Tkach, Inurrigarro, Schillaci, Cerchietti, Elizalde, Proietti: Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth. in Breast cancer research : BCR 2015
Show all 7 Pubmed References
Chicken Monoclonal EZH2 Primary Antibody for IF, WB - ABIN968906
Raaphorst, Otte, van Kemenade, Blokzijl, Fieret, Hamer, Satijn, Meijer: Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 2 Pubmed References
Chicken Monoclonal EZH2 Primary Antibody for IF, WB - ABIN968907
van Kemenade, Raaphorst, Blokzijl, Fieret, Hamer, Satijn, Otte, Meijer: Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. in Blood 2001
Show all 2 Pubmed References
Polyclonal EZH2 Primary Antibody for WB - ABIN540724
Hobert, Jallal, Ullrich: Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. in Molecular and cellular biology 1996
Show all 3 Pubmed References
Human Polyclonal EZH2 Primary Antibody for WB - ABIN2668964
Kaneko, Li, Son, Xu, Margueron, Neubert, Reinberg: Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. in Genes & development 2010
Show all 2 Pubmed References
Human Polyclonal EZH2 Primary Antibody for ICC, IF - ABIN438771
Hyland, McDade, McCloskey, Dickson, Arthur, McCance, Patel: Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes. in Journal of virology 2011
Human Monoclonal EZH2 Primary Antibody for IF, IHC (p) - ABIN659002
Tsai, Manor, Wan, Mosammaparast, Wang, Lan, Shi, Segal, Chang: Long noncoding RNA as modular scaffold of histone modification complexes. in Science (New York, N.Y.) 2010
Show all 6 Pubmed References
Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
Studies indicate that enhancer of zeste homolog 2 (EZH2) is a potential target for cancer therapy and a variety of inhibitors have been developed [review].
Confirmation of an oncogenic role for LINC00319 in clinical specimens and cellular experiments, showing the potential LINC00319/miR (show MLXIP Antibodies)-450b-5p/EZH2 pathway in lung adenocarcinoma tumorigenesis.
the present study showed that EZH2 was a potential prognostic marker for poor OS, PFS and lower KPS score in glioma patients.
Data show that the enhancer of zeste homolog 2 (EZH2) knockdown (using siRNA) or enzymatic inhibition (by GSK126) induced epithelial-to-mesenchymal transition (EMT (show ITK Antibodies))-like changes in ovarian cancer (OC) cells.
Results revealed that EZH2 interacted with the CpG site at the gene body of METTL7A (show METTL7A Antibodies) and was responsible for MBD2 (show DPEP2 Antibodies) recruitment as well as RNA pol II (show 0 Antibodies) rejection, which leads to METTL7A (show METTL7A Antibodies) silencing in thyroid cancer.
Results suggest that EZH2 is critical for the growth and metastasis of osteosarcoma.
Report a functional interaction between EZH2- and PIK3CA (show PIK3CA Antibodies)-dependent signaling pathways in non-muscle invasive bladder cancer cells.
we analyzed eight probands with clinically suspected Weaver syndrome by whole-exome sequencing and identified three mutations: a 25.4-kb deletion partially involving EZH2 and CUL1 ,a missense mutation , and a missense mutation in SUZ12 inherited from her father .In vitro functional analyses demonstrated that the identified EED and SUZ12 missense mutations cause decreased decreased trimethylation of lysine 27 of H3
Inhibition of EZH2 down-regulates myeloma associated oncogenes and up-regulates microRNAs with potential tumor suppressor functions in multiple myeloma cells.
EZH2, miRNA and beta-catenin (show CTNNB1 Antibodies) signaling have roles in aerobic glycolysis in glioma
EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A (show CDKN1A Antibodies) and release of cell cycle checkpoints.
Suggest that EZH1 (show EZH1 Antibodies) and -2 are novel targets of miR (show MLXIP Antibodies)-214-3p, and miR (show MLXIP Antibodies)-214-3p might be one potential miRNA for the prevention of cardiac fibrosis.
It has been demonstrated that FAK (show PTK2 Antibodies) depletion reduces hepatocellular carcinoma cell growth by affecting cancer-promoting genes including the pro-oncogene (show RAB1A Antibodies) EZH2.
ompounding a previously described Bmi1 (show BMI1 Antibodies)-transgene and Pten-deficiency prostate cancer mouse model with the Ezh2 transgene did not enhance tumour progression or drive metastasis formation. In conclusion, we here report the generation of a wildtype Ezh2 overexpression mouse model that allows for intravital surveillance of tissues with activated transgene
decline in HDAC9c expression over time was accompanied by increased EZH2 expression.
Long non-coding RNA LOC554202 may play an important role in the progression of chordoma by the direct upregulation of EZH2 and indirect promotion of RNF144B (show RNF144B Antibodies) via miR (show MLXIP Antibodies)-31
Gfi1 (show ZNF163 Antibodies) disruption antagonized the tumor-promoting effects of Ezh2 loss; conversely, Gfi1 (show ZNF163 Antibodies) overexpression collaborated with Myc (show MYC Antibodies) to bypass effects of Trp53 (show TP53 Antibodies) inactivation in driving medulloblastoma progression in primary cerebellar neuronal progenitors.
EZH2-deficient hESCs can initiate differentiation toward developmental lineages; however, they cannot fully differentiate into mature specialized tissues. Thus, EZH2 is required for stable ESC self-renewal, regulation of transcriptional programs, and for late-stage differentiation in this model of early human development.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
High EZH2 expression is associated with Neuroblastoma (show ARHGEF16 Antibodies).
Ezh2 is essential to sustain tissue integrity and to set up proper maternal mRNA contribution.
ezh2-deficient mutants fail to properly regenerate their spinal cord after caudal (show CAD Antibodies) fin transection suggesting that Ezh2 and H3K27me3 methylation might also be involved in the process of regeneration in zebrafish.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2