This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
Alternative names and synonyms associated with SNW1
SNW domain containing 1 (snw1) ELISA Kit
nuclear protein SkiP (PVX_002605) ELISA Kit
puff-specific protein Bx42 (LOC5564605) ELISA Kit
putative nuclear protein SkiP (Smp_105860) ELISA Kit