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anti-Human DDX6 Antibodies:
anti-Rat (Rattus) DDX6 Antibodies:
anti-Mouse (Murine) DDX6 Antibodies:
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Human Polyclonal DDX6 Primary Antibody for ICC, IF - ABIN152327
Nonhoff, Ralser, Welzel, Piccini, Balzereit, Yaspo, Lehrach, Krobitsch: Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. in Molecular biology of the cell 2007
Show all 31 Pubmed References
Human Polyclonal DDX6 Primary Antibody for ICC, IF - ABIN152328
Sivan, Kedersha, Elroy-Stein: Ribosomal slowdown mediates translational arrest during cellular division. in Molecular and cellular biology 2007
Show all 16 Pubmed References
Human Monoclonal DDX6 Primary Antibody for IHC (p), RNAi - ABIN560590
Broytman, Westmark, Gurel, Malter: Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines. in Neurobiology of aging 2009
Show all 3 Pubmed References
Dog (Canine) Polyclonal DDX6 Primary Antibody for ELISA, WB - ABIN547621
Cougot, Babajko, Séraphin: Cytoplasmic foci are sites of mRNA decay in human cells. in The Journal of cell biology 2004
Intermediate-sized non-coding RNA 761 could interact with DEAD-box helicase 6 (DDX6) to induce NTERA-2 (NT2 (testicular embryonal carcinoma cell)) cell apoptosis and proliferation inhibition via the p53 pathway.
The abrogation of DDX6 expression inhibited iPSC generation, which was mediated by RNA decay targeting parental mRNAs supporting mesenchymal phenotypes, along with microRNAs, such as miR-302b-3p
Results showed that DDX6 was overexpressed in gastric cancer (GC) and acted as an oncogene through the regulation of c-Myc mRNA in GC cells.
Results provide evidence for a dual mechanisms regulating the nucleocytoplasmic localization of DDX6. First, data show that DDX6 can be transported by 4E-T in a piggyback manner. Furthermore, a novel nuclear targeting mechanism was detected in which DDX6 enters the newly formed nuclei by "hitch-hiking" on mitotic chromosomes with its C-terminal domain during M phase progression.
Results showed that DDX6 protein was overexpressed in gastric cancer (GC) and provided evidence that DDX6 acted as an upstream molecule that positively regulated the expression of HER2 and FGFR2 at the post-transcriptional step in GC cells.
These findings imply a novel function for DDX6 as an RNA co-sensor and signaling enhancer for RIG-I.
Identification of the DEAD box RNA helicase DDX6 as a new partner that acts in cooperation with Tau to increase miRNA activity.
DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA.
we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis.
miRNAs, AGOs, GW182, the CCR4-NOT complex, and DDX6/Me31B repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells
DDX6 may have a role in radio- and chemoresistance in glioblastoma
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility.
DDX6 repression complexes are required for P-body assembly.
Protein Interactome Analysis of DDX6
Results indicate that progenitor function is maintained by DDX6 complexes through two distinct pathways that include the degradation of differentiation-inducing transcripts and by promoting the translation of self-renewal and proliferation mRNAs.
CNOT1 facilitates recruitment of DDX6 to miRNA-targeted mRNAs, placing DDX6 as a downstream effector in the miRNA silencing pathway.
study discovered multiple susceptibility variants for systemic lupus erythematosus in the 11q23.3 region, including variants in/near PHLDB1 (rs11603023), DDX6 (rs638893) and CXCR5 (rs10892301)
Crystal structures of the DDX6, CNOT1 and CNOT9 complexes.
Crystal structure of the DDX6, CNOT9 and CNOT1 complex.
DDX6 and miR-122 modulate HCV through distinct pathways.
Xp54nrb transcripts are expressed throughout early developmental stages, specifically in the neural and sensorial territories and Xp54nrb could be involved in anterior neural patterning
An oligomerized form of p54 RNA helicase represses mRNA translation.
DDX6 is a negative regulatory factor that negatively regulates milk synthesis and cell proliferation via inhibiting the mTOR, SREBP-1c, and cyclin D1 pathways.
The Ddx6 knockout cells were phenotypically and molecularly similar to cells lacking all microRNAs (Dgcr8 knockout ESCs). These data show that the loss of DDX6 can separate the two canonical functions of microRNAs: translational repression and transcript destabilization
Data show that RNA helicase DDX6 colocalizes with ubiquitin-protein ligase TRIM32 in neural stem cells and neurons and that it increases the activity of microRNA Let-7a.
rck/p54 may play an important role in gametogenesis and early embryogenesis in mammals
rck/p54 protein was ubiquitously expressed in mouse tissues
RCK/ p54 might be a determinant of colorectal cancer proliferation by activating the canonical Wnt pathway
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
, DEAD box protein 6
, RNA helicase p54
, probable ATP-dependent RNA helicase ddx6
, ATP-dependent RNA helicase p54
, DEAD box-6
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)
, oncogene RCK
, probable ATP-dependent RNA helicase DDX6
, ATP-dependent RNA helicase ddx6
, D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 6
, DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 6
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6
, oncogene RCK homolog