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anti-Mouse (Murine) MBNL1 Antibodies:
anti-Human MBNL1 Antibodies:
anti-Rat (Rattus) MBNL1 Antibodies:
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Human Polyclonal MBNL1 Primary Antibody for WB - ABIN1881533
Sen, Talukdar, Liu, Tam, Reddy, Webster: Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. in The Journal of biological chemistry 2010
Show all 5 Pubmed References
Human Monoclonal MBNL1 Primary Antibody for IF, IHC (p) - ABIN561753
Rehman, Gladman, Periasamy, Sun, Mahadevan: Development of an AP-FRET based analysis for characterizing RNA-protein interactions in myotonic dystrophy (DM1). in PLoS ONE 2014
Dog (Canine) Polyclonal MBNL1 Primary Antibody for IHC, WB - ABIN2776697
Coram, Stillwagon, Guggilam, Jenkins, Swanson, Ladd: Muscleblind-like 1 is required for normal heart valve development in vivo. in BMC developmental biology 2015
Human Polyclonal MBNL1 Primary Antibody for IHC, WB - ABIN2776698
Adereth, Dammai, Kose, Li, Hsu: RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1. in Nature cell biology 2005
Show all 3 Pubmed References
Human Polyclonal MBNL1 Primary Antibody for ELISA, WB - ABIN451638
Warf, Berglund: MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T. in RNA (New York, N.Y.) 2007
Mbnl1(+/-); Mbnl2 (show MBNL2 Antibodies)(+/-) knockout mice with myotonic dystrophy presented with clinical myofibril ultrastructural abnormality and cardiac arrhythmias.
our study uncovered a novel, autoregulatory function of MBNL proteins based on their binding to e1 of MBNL1 transcript. This function might facilitate cellular protection from MBNL protein level fluctuations, which might otherwise lead to adverse effects caused by extreme MBNL content.
Data show that Muscleblind-like 1 (Mbnl1) and Muscleblind-Like 3 (Mbnl3 (show MBNL3 Antibodies)) bind skeletal muscle chloride channel (show CLCA1 Antibodies) CIC-1 (Clc-1 (show CLCN1 Antibodies)) mRNA.
Depletion of Mbnl1 and/or Mbnl2 (show MBNL2 Antibodies) reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites
Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.
MBNL1 overexpression promotes transformation of fibroblasts into myofibroblasts.
These data indicate that MBNL1 plays a conserved role in negatively regulating TGFbeta (show TGFB1 Antibodies) signaling, and is required for normal valve morphogenesis and homeostasis in vivo.
this study supports a key role for Mbnl1 loss in the initiation of DM1 cardiac disease.
Differential expression of Mbnl1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.
Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.
For exogenous activation of MBNL transcription, MBNL1 transcription start site T2 seems to be the most suitable target, as the ensuing pre-mRNA is susceptible to both major loops, e1 and e5, and hence, theoretically, following induction each cell in the body could reach the optimal MBNL content.
RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2
Our work suggests that DM1 (show DMPK Antibodies) patients are at risk for Fuchs' endothelial corneal dystrophy (FECD (show COL8a2 Antibodies)). DMPK (show DMPK Antibodies) mutations contribute to the genetic burden of FECD (show COL8a2 Antibodies) but are uncommon. We establish a connection between two repeat expansion disorders converging upon RNA-MBNL1 foci and FECD (show COL8a2 Antibodies).
Binding of the MBNL zinc fingers to cardiac troponin T (show TNNT2 Antibodies) pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies.
Heterozygous missense mutations and one in-frame deletion in MBNL1 were identified in 3 myotonic dystrophy patients.
Nuclear retention of full-length HTT (show HTT Antibodies) RNA is mediated by splicing factors MBNL1 and U2AF65 (show U2AF59 Antibodies)
muscleblind-like 1 (MBNL1) is a robust suppressor of multiorgan breast cancer metastasis. It binds the 3' untranslated regions of DBNL (show DBNL Antibodies) and TACC1 (show TACC1 Antibodies) -two genes that are implicated as metastasis suppressors.
abnormal splicing of DMD (show DMD Antibodies) exon 78 found in dystrophic muscles of DM1 (show DMPK Antibodies) patients is due to the functional loss of MBNL1 and leads to the re-expression of an embryonic dystrophin (show DMD Antibodies) in place of the adult isoform.
Reduced RBFOX1 (show A2BP1 Antibodies) activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1.
Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).
, muscleblind-like (Drosophila)
, muscleblind-like protein 1
, muscleblind-like 1
, triplet-expansion RNA-binding protein