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Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are performed by 2 separate enzymes, phosphopantetheine adenylyltransferase (PPAT\; EC 188.8.131.52) and dephospho-CoA kinase (DPCK\; EC 184.108.40.206), in prokaryotes (Daugherty et al., 2002
bifunctional coenzyme A synthase
, bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase
, nucleotide binding protein
, phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase
, Coenzyme A synthase
, 4'-phosphopantetheine adenylyltransferase and dephospho-CoA kinase
, CoA synthase
, hypothetical protein
, bifunctional phosphopantetheine adenylyl transferase / dephospho CoA kinase