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RARalpha regulates Arp2/3-mediated actin cytoskeletal dynamics through a non-genomic signaling pathway
We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects.
evidence of a direct protein-protein interaction between PKD2 (show PKD2 Proteins) and Arp2/3
miR (show MLXIP Proteins)-24-1*/let-7a*-ARP2/3 complex-RAC (show AKT1 Proteins) isoforms pathway may represent a novel pathogenic mechanism for Hirschsprung disease.
this study identified roles for ARP2 and filopodia in human respiratory syncytial virus -induced cell motility, virus production, and cell-to-cell spread.
Arp2 and Arp3 (show ACTR3 Proteins) expression was increased under atherosclerotic conditions both in ApoE (show APOE Proteins)-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs).
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (show VPS72 Proteins) in U251 human glioma cells.
Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13.
demonstrate that the Arp2/3 complex in higher eukaryotes is actually a family of complexes with different properties
Platelet actin nodule formation is dependent on WASp and the ARP2/3 complex.
We find that the expression of the actin polymerization complex Arp2/3 is reduced in dysbindin-deficient cells, thus affecting actin-dependent phenotypes
Arp2 (show AICDA Proteins) and Arp3 (show ANGPTL6 Proteins) expression was increased under atherosclerotic conditions both in ApoE (show APOE Proteins)-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs).
Dendritic cells possess a mechanism to pass through micrometric constrictions. This mechanism is based on a rapid Arp2/3-dependent actin nucleation around the nucleus that disrupts the nuclear lamina, the main structure limiting nuclear deformability.
demonstrate that the Arp2 (show AICDA Proteins)/3 complex in higher eukaryotes is actually a family of complexes with different properties
Platelet actin nodule formation is dependent on WASp and the ARP2 (show AICDA Proteins)/3 complex.
Arp2/3 complex is an essential regulator of adipocyte development through control of the formation of cortical actin structures, which may facilitate nutrient uptake and signalling events.
WASH complex regulates Arp2 (show AICDA Proteins)/3 complex and is required for cytokinesis and polar body extrusion.
Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
The Arp2 (show AICDA Proteins)/3 complex may regulate mouse embryo development via its effect on cell division.
Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
crystal structure of Arp2/3 complex
These results demonstrate an important role for CRMP-1 (show CRMP1 Proteins) in Listeria actin comet tail formation and open the possibility that CRMP-1 (show CRMP1 Proteins) controls cell motility by modulating Arp2/3 activation.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
interacts with contactin and N-WASp
Data show that L. monocytogenes motility can be separated into an Arp2/3-dependent nucleation phase, and an Arp2/3-independent elongation phase which is dependent upon fascin (show FSCN1 Proteins).
crystal structures of Arp2/3 complex with bound ATP or ADP
WASp stabilizes p35-dependent closure of the complex, holding Arp2 and Arp3 closer together to nucleate an actin filament.
domain rearrangements of Arp2 and Arp3 result in a closed conformational state consistent with an "actin-dimer" model for the active state
Arp2/3 complex regulates mitochondrial-dependent Ca(2 (show CA2 Proteins)+) signaling in response to salt stress.Arp2 is required for mitochondrial distribution.
The work indicates that regulation of actin reassembly through ARP2/3 complex activity is crucial for stomatal regulation.
The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex.
BRK1 (show BRK1 Proteins) is required for accumulation of SCAR1 (show WASF1 Proteins) protein in vivo, potentially explaining the apparently essential role of BRK1 (show BRK1 Proteins) in ARP2/3 complex function
Differences among SCARs in mRNA levels and the biochemical efficiency of ARP2/3 activation may explain the functional contributions of individual genes
The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.
The specific function of this gene has not yet been determined\; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.
actin-like protein 2
, actin-related protein 2
, ARP2 actin-related protein 2 homolog
, actin-like protein ACTL
, actin-like protein 2-A
, actin-related protein 2-A
, ARP2 actin-related protein 2 homolog (yeast)
, Actin-related protein 2
, actin-related protein 2-like
, actin-related protein T2
, actin-related protein M2
, actin-related protein Arp2
, ARP2 actin-related protein 2
, actin-like protein 2-B
, actin-related protein 2-B
, Actin-like protein 2