Browse our anti-Angiopoietin 2 (ANGPT2) Antibodies

Human Angiopoietin 2 (ANGPT2) interaction partners

1. Flunarizine protected ECs from TNFalpha (show TNF Antibodies)-induced increase in Angpt-2 transcription and vascular barrier breakdown.

2. Study findings delineate the existence of the beta-estradiol (E2)-ANGPT2 axis in hair follicles and suggest that, by substituting E2, ANGPT2 may provide a novel strategy for the treatment of postmenopausal female pattern hair loss.

3. Results suggest that hCPFs-Exo (show PHM Antibodies) transports low expressed exosomal miR (show MLXIP Antibodies)-106b-5p to endothelial cells and promotes angiogenesis by overexpression of Angpt2.

4. Angpt2 is an independent predictor of adverse clinical outcomes in diabetic patients. Further studies are needed to identify the pathogenic role of Angpt2 in renal deterioration and cardiovascular complications of diabetes mellitus.

5. High ANG2 expression is associated with Acute respiratory distress syndrome.

6. PVT1 was able to bind and degrade miR26b to promote connective tissue growth factor (CTGF (show CTGF Antibodies)) and angiopoietin 2 (ANGPT2) expression.

7. Serum Ang-2 may be a useful tumor marker in predicting liver cancer prognosis.

8. High ANG2 expression is associated with angiogenesis in breast cancer.

9. Angiopoietin-2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout Tie-2 (show TEK Antibodies) receptor engagement.

10. High Angpt2 and low Angpt1 (show ANGPT1 Antibodies) levels were positively associated with abnormal cardiac structure.

Mouse (Murine) Angiopoietin 2 (ANGPT2) interaction partners

1. Flunarizine protected ECs from TNFalpha (show TNF Antibodies)-induced increase in Angpt-2 transcription and vascular barrier breakdown.

2. At the molecular level NLGN2 (show NLGN2 Antibodies) colocalizes with its neuronal partner collibystin, a CDC42 (show CDC42 Antibodies) guanine nucleotide exchange factor (show ARHGEF12 Antibodies), which is also expressed by endothelial cells and in turn modulates Angiopoietin 2 release.

3. ANGPT2-TIE2 (show TEK Antibodies) signaling is essential for mesenteric lymphatic development.VEPTP (vascular endothelial protein tyrosine phosphatase (show PTPRB Antibodies)) determines TIE2 (show TEK Antibodies) response to ANGPT2.

4. Endothelial glycocalyx breakdown is mediated by Angpt-2 in a non-redundant manner.

5. These results indicate that the Angpt-Tie2 (show TEK Antibodies) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (show TEK Antibodies) agonists could be a therapeutic option for glaucoma.

6. ANG2 activation of Tie2 (show TEK Antibodies) supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (show TIE1 Antibodies) in inflammation leads to ANG2 antagonism of Tie2 (show TEK Antibodies) and initiates a positive feedback loop wherein FOXO1 (show FOXO1 Antibodies)-driven ANG2 expression promotes vascular remodeling and leakage

7. A balanced expression of the Ang1 (show ANGPT1 Antibodies)/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis

8. These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.

9. NDPKB (show NME1 Antibodies) is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.

10. miR (show MLXIP Antibodies)-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.

Zebrafish Angiopoietin 2 (ANGPT2) interaction partners

1. Shear stress activated Ang-2 via canonical Wnt (show WNT2 Antibodies) signaling in vascular endothelial cells, and Wnt (show WNT2 Antibodies)-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.

Cow (Bovine) Angiopoietin 2 (ANGPT2) interaction partners

1. Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha (show HIF1A Antibodies) binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.

2. Activation of the PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway could affect the angiogenic process.

3. Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.

4. In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.

Pig (Porcine) Angiopoietin 2 (ANGPT2) interaction partners

1. expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus

2. ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.

Rabbit Angiopoietin 2 (ANGPT2) interaction partners

1. forward mandibular positioning enhance the expression of Ang1 (show ANGPT1 Antibodies) and Ang2 in condylar cartilage.

2. These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.