Browse our anti-Angiopoietin 2 (ANGPT2) Antibodies

Human Angiopoietin 2 (ANGPT2) interaction partners

1. Study in cultured HUVEC cells demonstrated that the upregulation of ANG2 upon NDPK-B deficiency (siRNA knockdown) is driven by O-GlcNAcylation of FOXO1 and provide evidence for a central role of protein O-GlcNAcylation in NDPK-B associated vascular damage and point to the hexosamine pathway as an important target in retinal vasoregression.

2. The current study demonstrates a pro-angiogenic role of Fzd5, which was shown to be involved in endothelial tubule formation, cell cycle progression and migration, and partly does so by repression of PKC/Ets1-mediated transcription of Flt1 and Angpt2.

3. Biweekly vanucizumab had an acceptable safety and tolerability profile consistent with single-agent use of selective inhibitors of the VEGF-A and Ang/Tie2 pathway.

4. Our findings implicate CD177 as a biomarker for bevacizumab and suggest VEGF/Ang2 inhibition as a strategy to overcome neutrophil associated resistance to anti-angiogenic treatment

5. circulating Ang-2 levels have an effect on all-cause mortality and cardiovascular events in peripheral artery disease

6. Results show that the expression levels of vascular endothelial growth factor A (VEGFA), angiopoietin-2 (ANGPT2), and tissue plasminogen activator (PLAT) were suppressed in ADAM9-silenced cells, which in turn leads to decreases in angiogenesis, vascular remodeling, and tumor growth in vivo.

7. Serum Angpt-2 showed close association with valvular calcification, atherosclerosis, inflammation and malnutrition, having significant independent prognostic value and is useful for cardiovascular event stratification in chronic peritoneal dialysis patients.

8. Ang-2/Ang-1 ratio higher in children with septic shock

9. SNPs rs2442598, rs734701, rs1823375 and rs12674822 associated with rheumatoid arthritis susceptibility

10. Angiopoietin-2 (ANGPT2) was significantly up-regulated in primary thoracic ligamentum flavum cells during osteogenic differentiation. To address the effect of ANGPT2 on Notch signaling and osteogenesis, ANGPT2 stimulation increased the expression of Notch2 and osteogenic markers of primary thoracic ligamentum flavum cells of immature ossification.

11. we outline the roles of VEGF and ANG2 in tumour immune evasion and progression, and discuss the evidence indicating that antiangiogenic agents can normalize the tumour microenvironment

12. the relation of Ang2 and Tie2 with inflammation markers in the general population, was examined.

13. Serum Ang 2 can reflect the degree of endothelial and vasodilation impairment in hypertensive patients

14. Glioma stromal cells, oligodendrocytes, might up-regulate the invasiveness of glioblastoma cells via angiopoietin-2 signaling

15. plasma ANG-2 level, the acute physiology and chronic health evaluation 2 (APACHE2) score and lung injury prediction score are correlated with acute respiratory distress syndrome

16. Study is the first to demonstrate that Ang2 is upregulated not only in the local skin lesions but also in the systemic circulation, and that its serum levels correlate well with disease severity in psoriasis vulgaris patients.

17. regulatory mechanisms of Ang-2 in NSCLC

18. This study demonstrates that Ang-2 levels are significantly upregulated in sepsis-associated coagulopathy (SAC), and this biomarker can be used to risk stratify patients with sepsis into non-overt disseminated intravascular coagulation (DIC) and overt DIC.

19. Flunarizine protected ECs from TNFalpha-induced increase in Angpt-2 transcription and vascular barrier breakdown.

20. Study findings delineate the existence of the beta-estradiol (E2)-ANGPT2 axis in hair follicles and suggest that, by substituting E2, ANGPT2 may provide a novel strategy for the treatment of postmenopausal female pattern hair loss.

Mouse (Murine) Angiopoietin 2 (ANGPT2) interaction partners

1. Study in transgenic mice and cultured HUVEC cells reports that the increased levels of Ang-2 are indeed crucial for the development of retinal damage under NDPK-B deficiency and provides evidence that the enhanced O-GlcNAcylation of FoxO1 after NDPK-B depletion is regulating its protein expression and thereby driving the upregulation of Ang-2 in endothelial cells.

2. Late gestational deletion of the angiopoietin receptor endothelial tyrosine kinase 2 (Tie2) or both angiopoietin-1 and angiopoietin-2 prevents ascending vasa recta formation in mice. The AVRs are Tie2 signaling-dependent specialized hybrid vessels.

3. inhibition of Angpt2 either by gene deletion or using an anti-Angpt2 blocking antibody substantially alleviated these pathological findings and ameliorated postischemic cardiovascular remodeling. Blockade of Angpt2 thus has potential as a therapeutic option for ischemic heart failure.

4. Flunarizine protected ECs from TNFalpha-induced increase in Angpt-2 transcription and vascular barrier breakdown.

5. At the molecular level NLGN2 colocalizes with its neuronal partner collibystin, a CDC42 guanine nucleotide exchange factor, which is also expressed by endothelial cells and in turn modulates Angiopoietin 2 release.

6. ANGPT2-TIE2 signaling is essential for mesenteric lymphatic development.VEPTP (vascular endothelial protein tyrosine phosphatase) determines TIE2 response to ANGPT2.

7. Endothelial glycocalyx breakdown is mediated by Angpt-2 in a non-redundant manner.

8. These results indicate that the Angpt-Tie2 system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 agonists could be a therapeutic option for glaucoma.

9. ANG2 activation of Tie2 supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 in inflammation leads to ANG2 antagonism of Tie2 and initiates a positive feedback loop wherein FOXO1-driven ANG2 expression promotes vascular remodeling and leakage

10. A balanced expression of the Ang1/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis

11. These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.

12. NDPKB is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.

13. miR-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.

14. Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.

15. The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 and Ang2.

16. Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 expression

17. ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development

18. This study identifies angiopoietin-2 as a link between kidney fibrosis and arterial stiffness.

19. vitamin D-VDR signaling prevents lung injury by blocking the Ang-2-Tie-2-MLC kinase cascade and the renin-angiotensin system.

20. Angiopoietin-2 was expressed on lymphatic vessels and macrophages in inflamed cornea. While corneal LG response was abolished in Ang-2 knockout mice.

Zebrafish Angiopoietin 2 (ANGPT2) interaction partners

1. Shear stress activated Ang-2 via canonical Wnt signaling in vascular endothelial cells, and Wnt-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.

Cow (Bovine) Angiopoietin 2 (ANGPT2) interaction partners

1. polymorphisms significantly associated with milk somatic cell score

2. Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.

3. The mRNA expression for ANPT-2 was drastically decreased in the follicles with E(2)>5 ng/ml.

4. Activation of the PI3-K/Akt pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K/Akt pathway could affect the angiogenic process.

5. Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.

6. In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.

Pig (Porcine) Angiopoietin 2 (ANGPT2) interaction partners

1. The presence of angiopoietins in the trophoblast suggests a specific role for these pro-angiogenic factors in the tissue formation at the maternal-fetal interface.

2. expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus

3. ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.

Rabbit Angiopoietin 2 (ANGPT2) interaction partners

1. forward mandibular positioning enhance the expression of Ang1 and Ang2 in condylar cartilage.

2. These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.