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anti-Human Angiopoietin 2 Antibodies:
anti-Mouse (Murine) Angiopoietin 2 Antibodies:
anti-Rat (Rattus) Angiopoietin 2 Antibodies:
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Human Polyclonal Angiopoietin 2 Primary Antibody for FACS, IHC (p) - ABIN654062
Morrissey, Dowell, Koreckij, Nguyen, Lakely, Fanslow, True, Corey, Vessella: Inhibition of angiopoietin-2 in LuCaP 23.1 prostate cancer tumors decreases tumor growth and viability. in The Prostate 2010
Show all 3 Pubmed References
Human Polyclonal Angiopoietin 2 Primary Antibody for IF (p), IHC (p) - ABIN671781
Lv, Fan, Su: Is a swine model of arteriovenous malformation suitable for human extracranial arteriovenous malformation? A preliminary study. in Cardiovascular and interventional radiology 2013
Show all 2 Pubmed References
Chicken Monoclonal Angiopoietin 2 Primary Antibody for ICC, IHC (fro) - ABIN259881
Laquer, Dao, Pavlis, Nguyen, Chen, Harris, Rugg, Kelly: Immunohistochemistry of angiogenesis mediators before and after pulsed dye laser treatment of angiomas. in Lasers in surgery and medicine 2012
Show all 2 Pubmed References
Human Polyclonal Angiopoietin 2 Primary Antibody for WB - ABIN95113
Davis, Aldrich, Jones, Acheson, Compton, Jain, Ryan, Bruno, Radziejewski, Maisonpierre, Yancopoulos: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. in Cell 1997
Human Polyclonal Angiopoietin 2 Primary Antibody for IHC, IHC (p) - ABIN4280609
Zhou, Fang, Shang, Zhang, Sang, Xu, Yuan, Chen, Zheng, Zhang, Zhuang: MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. in The Journal of pathology 2016
Serum Ang-2 may be a useful tumor marker in predicting liver cancer prognosis.
High ANG2 expression is associated with angiogenesis in breast cancer.
Angiopoietin-2 acts as a survival factor for chronic lymphocytic leukemia B cells throughout Tie-2 (show TEK Antibodies) receptor engagement.
High Angpt2 and low Angpt1 (show ANGPT1 Antibodies) levels were positively associated with abnormal cardiac structure.
Plasma levels of Ang2 were associated with markers of malaria severity and levels of var transcripts encoding P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) containing Cysteine Rich Inter Domain Region alpha1 (CIDRalpha1) domains predicted to bind Endothelial Protein C receptor (EPCR (show PROCR Antibodies)).
Hepatitis C virus induces Ang2 expression in hepatocytes.
the relationship between lung cancer stage and Ang 2 was documented with this study and the expression rate was found to be lower in adenocarcinomas. By this analysis, we can suggest that angiopoietins may be used as an option for targeted treatment in lung cancer.
Endothelial glycocalyx breakdown is mediated by Angpt-2 in a non-redundant manner.
serum Ang-2 and Ang-1 (show ANGPT1 Antibodies) levels may help in the diagnosis of patients with lymphatic anomalies and are concordant to sirolimus response.
Studied role of change in ratio of angiopoietin-2 (Ang-2) to angiopoietin-1 (Ang-1 (show ANGPT1 Antibodies)) levels in hantavirus ionfections. Found imbalance in ang-2:ang-1 (show ANGPT1 Antibodies) lasted through the acute infection phase.
ANGPT2-TIE2 (show TEK Antibodies) signaling is essential for mesenteric lymphatic development.VEPTP (vascular endothelial protein tyrosine phosphatase (show PTPRB Antibodies)) determines TIE2 (show TEK Antibodies) response to ANGPT2.
These results indicate that the Angpt-Tie2 (show TEK Antibodies) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (show TEK Antibodies) agonists could be a therapeutic option for glaucoma.
ANG2 activation of Tie2 (show TEK Antibodies) supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (show TIE1 Antibodies) in inflammation leads to ANG2 antagonism of Tie2 (show TEK Antibodies) and initiates a positive feedback loop wherein FOXO1 (show FOXO1 Antibodies)-driven ANG2 expression promotes vascular remodeling and leakage
A balanced expression of the Ang1 (show ANGPT1 Antibodies)/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB (show NME1 Antibodies) is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR (show MLXIP Antibodies)-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 (show ANGPT1 Antibodies) and Ang2.
Shear stress activated Ang-2 via canonical Wnt (show WNT2 Antibodies) signaling in vascular endothelial cells, and Wnt (show WNT2 Antibodies)-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha (show HIF1A Antibodies) binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 (show ANGPT1 Antibodies) and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, angiopoietin 2
, Angiopoietin-2B (Ang-2B)