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Human Angiopoietin 2 Protein expressed in HEK-293 Cells - ABIN1344329
Kim, Shin, Kim, Choi, Byun, Jeon, Suh, Kim: Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells. in Cardiovascular research 2006
Human Angiopoietin 2 Protein expressed in HEK-293 Cells - ABIN2870605
Kang, Kim, Jeong, Im: Angiopoietin-2 Enhances Osteogenic Differentiation of Bone Marrow Stem Cells. in Journal of cellular biochemistry 2017
Shear stress activated Ang-2 via canonical Wnt signaling in vascular endothelial cells, and Wnt-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
These results indicate that the Angpt-Tie2 (show TEK Proteins) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (show TEK Proteins) agonists could be a therapeutic option for glaucoma.
ANG2 activation of Tie2 supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 in inflammation leads to ANG2 antagonism of Tie2 and initiates a positive feedback loop wherein FOXO1-driven ANG2 expression promotes vascular remodeling and leakage
A balanced expression of the Ang1/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (show IL18 Proteins) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
We demonstrate that ANGPT2 signaling activated after estrogen depletion paradoxically triggers ER+ tumor cell awakening from dormancy in their BM niche, partly indirectly via endothelial Tie2 (show TEK Proteins) receptor and partly directly via tumor cell surface integrin &1.
ANG2 did not affect apoptosis or the cell cycle. In contrast, in the in vivo system, overexpression of ANG2 increased tumor growth.
When Tie2 (show TEK Proteins) becomes inactivated, important molecular brakes are released in the endothelium, which in turn potentiate inflammation and vascular leakage. The ligands of Tie2 (show TEK Proteins), Angiopoietin-1 (show ANGPT1 Proteins) and Angiopoietin-2, regulate its activation status.
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (show IL6 Proteins) (40.2pg/mL), VEGF-A (show VEGFA Proteins) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (show PRAP1 Proteins) (248.1pg/mL), sHER-2/neu (show ERBB2 Proteins) (5010pg/mL) and PLGF (show PGF Proteins) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
Gab1/SHP2 (show PTPN11 Proteins)/p38MAPK (show MAPK14 Proteins) signaling pathway and Ang-2 have an essential role in regulating thrombin (show F2 Proteins)-induced monocyte adhesion and vascular leakage
This study demonstrated that ANGPT2 higher expression in glioblastoma.
These observations provide the first evidence for positive regulation of osteogenesis by ANGPT2 in vitro.
in vitro is has also been shown that Angpt-2 can act as a dose-dependent Tie2 (show TEK Proteins) agonist/antagonist.
Ang-2 and sTie-2 plasma levels are increased in pediatric OSA and obesity, particularly when endothelial dysfunction or insulin (show INS Proteins) resistance is detectable.
pathways for two distinctive secretory mechanisms, constitutive and stimulated, of Ang-2 in pulmonary microvascular endothelial cells.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)